博落回鲜叶中生物碱类化学成分的分离与结构鉴定 |
投稿时间:2017-02-20 点此下载全文
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引用本文:杨鹏,向锋,卿志星,曹华亮,曾建国.博落回鲜叶中生物碱类化学成分的分离与结构鉴定[J].中国现代中药,2017,19(10):1371-1375 |
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基金项目:湖南省科技重点计划(2016SK3002) |
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中文摘要:目的:研究博落回叶的化学成分。方法:采用硅胶柱色谱以及制备液相色谱法进行分离纯化,并根据波谱数据鉴定化合物结构。结果:从博落回新鲜叶的乙醇提取物中分离纯化得到14个生物碱,分别鉴定为:原阿片碱(1)、别隐品碱(2)、血根碱(3)、白屈菜红碱(4)、去甲基白屈菜红碱(5)、去氢紫堇碱(6)、N-甲基四氢黄连碱(7)、黄柏碱(8)、6-甲氧基去甲基血根碱(9)、6-氰基二氢血根碱(10)、6-氰基二氢白屈菜红碱(11)、6-丙酮基二氢血根碱(12)、二氢血根碱(13)、二氢白屈菜红碱(14)。结论:其中化合物5~9为首次在博落回属植物中分离得到。 |
中文关键词:博落回 叶 生物碱 |
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Isolation and Identification of Alkaloids from Fresh Leaves of Macleaya cordata |
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Abstract:Objective:To study the alkaloids from the leaf of Macleaya cordata.Methods:The alkaloids were isolated and purified by silica gel column chromatography and preparative liquid chromatography,and the structures were elucidated based on the spectral data.Results:14 alkaloids were obtained from the fraction of ethanol extract and identified as protopine (1),allocryptopine (2),sangunarine (3),chelerythrine (4),Norcheleryth-rine (5),dehydrocorydaline (6),N-methyltetrahydrocoptisine (7),phellodendrine (8),6-methoxyldemethylsanguin-arine (9),6-cyanodihydrosangunarine (10),6-cyanodihydrochelerythrine (11),6-acetonyldihydrosangunarine (12),dihydrosangunarine (13) and dihydrochelerythrine (14).Conclusion:Compounds 5-9 are isolated from Macleaya cordata for the first time. |
keywords:Macleaya cordata (Willd) R.Br. leaf alkaloids |
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