博落回鲜叶中生物碱类化学成分的分离与结构鉴定
投稿时间:2017-02-20     点此下载全文
引用本文:杨鹏,向锋,卿志星,曹华亮,曾建国.博落回鲜叶中生物碱类化学成分的分离与结构鉴定[J].中国现代中药,2017,19(10):1371-1375
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作者中文名作者英文名单位中文名单位英文名E-Mail
杨鹏 YANG Peng 湖南中医药大学 药学院,湖南长沙410208 College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China  
向锋 XIANG Feng 国家中药材生产(湖南)技术中心,湖南长沙410128 Hunan Co-innovation Center for Utilization of Botanicals Functional Ingredients,Changsha 410128,China  
卿志星 QING Zhixing 国家中药材生产(湖南)技术中心,湖南长沙410128 Hunan Co-innovation Center for Utilization of Botanicals Functional Ingredients,Changsha 410128,China  
曹华亮 CAO Hualiang 湖南农业大学 兽用中药资源与中兽药创制国家地方联合工程研究中心,湖南长沙410128 National and Provincial Union Engineering Research Center for the Veterinary Herbal Medicine Resources and Initiative,Hunan Agricultural University,Changsha 410128,China  
曾建国 ZENG Jianguo 湖南中医药大学 药学院,湖南长沙410208 College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China 曾建国,教授,研究方向:中药资源与综合利用;Tel:(0731)84673824,E-mail:zengjianguo@hunau.edu.cn 
基金项目:湖南省科技重点计划(2016SK3002)
中文摘要:目的:研究博落回叶的化学成分。方法:采用硅胶柱色谱以及制备液相色谱法进行分离纯化,并根据波谱数据鉴定化合物结构。结果:从博落回新鲜叶的乙醇提取物中分离纯化得到14个生物碱,分别鉴定为:原阿片碱(1)、别隐品碱(2)、血根碱(3)、白屈菜红碱(4)、去甲基白屈菜红碱(5)、去氢紫堇碱(6)、N-甲基四氢黄连碱(7)、黄柏碱(8)、6-甲氧基去甲基血根碱(9)、6-氰基二氢血根碱(10)、6-氰基二氢白屈菜红碱(11)、6-丙酮基二氢血根碱(12)、二氢血根碱(13)、二氢白屈菜红碱(14)。结论:其中化合物5~9为首次在博落回属植物中分离得到。
中文关键词:博落回    生物碱
 
Isolation and Identification of Alkaloids from Fresh Leaves of Macleaya cordata
Abstract:Objective:To study the alkaloids from the leaf of Macleaya cordata.Methods:The alkaloids were isolated and purified by silica gel column chromatography and preparative liquid chromatography,and the structures were elucidated based on the spectral data.Results:14 alkaloids were obtained from the fraction of ethanol extract and identified as protopine (1),allocryptopine (2),sangunarine (3),chelerythrine (4),Norcheleryth-rine (5),dehydrocorydaline (6),N-methyltetrahydrocoptisine (7),phellodendrine (8),6-methoxyldemethylsanguin-arine (9),6-cyanodihydrosangunarine (10),6-cyanodihydrochelerythrine (11),6-acetonyldihydrosangunarine (12),dihydrosangunarine (13) and dihydrochelerythrine (14).Conclusion:Compounds 5-9 are isolated from Macleaya cordata for the first time.
keywords:Macleaya cordata (Willd) R.Br.  leaf  alkaloids
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