| 蒙药漆树膏的炮制工艺及质量标准研究 |
| 投稿时间：2017-01-16 点此下载全文
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| 引用本文：包勒朝鲁,吴·斯琴毕力格,那生桑,乌兰图雅.蒙药漆树膏的炮制工艺及质量标准研究[J].中国现代中药,2017,19(10):1454-1460 |
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| 基金项目:内蒙古自治区科技计划项目(20151230) |
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| 中文摘要:目的：建立蒙药漆树膏炮制规范。方法：根据蒙医药文献记载，筛选漆树膏的蒙医炮制的代表性、可行性方法，通过正交试验设计，优化该方法的工艺，并参照《中华人民共和国药典》（2015年版·四部）相关方法，采用三氯化铁显色反应，鉴定酚类化合物；对供试品水分、灰分、浸出物进行检测；采用紫外分光光度法，以没食子酸为对照，在759.5 nm波长下对供试品的活性成分总酚进行定量分析。结果：漆树膏的最理想的炮制方法为黄油制，其最佳工艺条件为药材和黄油比例1∶3，黄油表面温度为200 ℃，浸炮时间为20 min。炮制品三氯化铁显色反应为阳性；三批样品水分含量在6.59%～11.28%；总灰分含量在3.02%～7.55%；酸不溶性灰分含量在1.15%～4.49%；醇溶性浸出物含量在9.55%～22.97%；总酚在0.182～1.254 mg·L-1呈良好的线性关系，该方法平均回收率为99.31%，RSD为1.55%，总酚含量在10.34～20.45 mg·g-1。结论：本炮制方法不仅符合漆树膏的蒙医传统炮制品目的，也吻合现代药学理论，是一种较为理想的炮制工艺。 |
| 中文关键词:蒙药 漆树膏 没食子酸 总酚 紫外分光光度法 质量标准 |
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| Study on Processing Technology and Quality Standard of Mongolian Medicine Qishugao |
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| Abstract:Objective：To establish the processing standard of Mongolian medicine Qishugao.Methods：According to literature，the representative processing method was selected，and optimized through orthogonal design.Referring to the China Pharmacopoeia （2015），the relevant method was used to identify phenols，and measure water content，ash content and ethanolic extract.The total phenol as active component was detected with gallic acid as reference substance by spectrometric method.Results：The optimal preparation for Qishugao was butter cream processing，the condition was as follows：drug and butter ratio 1∶3，butter the surface temperature 200 ℃，soaking time 20 min.The color reaction of ferric chloride was positive.The water content of the three batches was between 6.59%-11.28%.The total ash content was between 3.02%-7.55%.The content of acid-insoluble ash was between 1.15%-4.49%.The content of alcohol soluble extract was between 9.55%-22.97%.The total phenol content was 0.182-1.254 mg·L-1.The average recovery was 99.31%，RSD was 1.55%，and the total phenol content was between 10.34-20.45 mg·g-1.Conclusion：The processing method is consistent with modern technology，it also follows traditional Mongolian medicine experience. |
| keywords:Mongolian medicine Qishugao gallic acid total phenols UV quality standard |
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