| 人参中农药残留在水煎及研粉吞服两种用药方式下溶出转移情况研究 |
| 投稿时间：2017-08-29 点此下载全文
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| 引用本文：杨婉珍,吕朝耕,康传志,王升,周良云,周利,蒋靖怡,李佳兴,郭兰萍.人参中农药残留在水煎及研粉吞服两种用药方式下溶出转移情况研究[J].中国现代中药,2018,20(6):729-733 |
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| 基金项目:国家自然科学基金项目（81325023，81473307），国家重点研发计划（2017YFC1700701，2017YFC1701405），中国中医科学院重点领域（ZZ10-027）、财政部中央本级专项（2060302）；发改委标准化项目（ZYBZH-C-HLJ-17，ZYBZH-C-GD-07） |
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| 中文摘要:目的：考察水煎及粉末直接服用两种用药方式下人参中残留农药的溶出情况，为中药材农残风险评估及标准制定提供参考。方法：参考《中华人民共和国药典》对6批人参饮片中70项农药残留进行检测，进而以有检出的7种农药腐霉利、六氯苯、五氯硝基苯、毒死蜱、乐果、马拉硫磷、亚胺硫磷为指标，对人参水煎液及加入人参粉末反应后的人工胃肠液中的农残溶出进行测定分析。结果：腐霉利、六氯苯和五氯硝基苯3种农药在水煎液及人工胃肠液中均有检出，溶出率分别为腐霉利0.92%、11.46%，六氯苯0.42%、4.95%，五氯硝基苯0.02%、1.76%，其余农药则均未能检测到。结论：煎煮和研粉吞服两种日常用药方式下，人参中农药残留均只有少量溶出，溶出率均低于12%。特别是在水煎这种最普遍的中药使用方式下，3种残留农药溶出率均低于1%，提示在中药材农药残留风险评估时应充分考虑中药材使用方式的特殊性，与一般食品相区别。本研究以人参为例，对两种用药方式下中药材农残溶出情况进行了初步研究，以期为中药材农药残留标准的制定提供思路与基础数据。 |
| 中文关键词:农残 人参 水煎液 人工胃肠液 溶出率 |
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| Dissolution Rate of Pesticide Residues in Ginseng Radix et Rhizoma under Two Medication Methods |
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| Abstract:Objective：To provide a basis for making standard of pesticide residues in Traditional Chinese medicines，we investigated the dissolution of pesticide residues in Ginseng Radix et Rhizoma under two medication methods of decoction and powder directly.Methods：Refer ring to the “Chinese Pharmacopoeia” for the detection of 70 pesticide residues in ginseng preparations，and using the 7 pesticides identified as indicators，the content of procymidone，hexachlorobenzene，quintozene，chlorpyrifos，dimethoate，malathion and phosmet in decoction and the artificial gastrointestinal fluid were measured and analyzed.Results：Procymidone，hexachlorobenzene and quintozene were detected in both decoction and artificial gastrointestinal fluid.The dissolution rates were 0.92%，11.46% for Procymidone；0.42%，4.95% for hexachlorobenzene；0.02%，1.76% for quintozene，and other pesticides were not detected.Conclusion：No matter whether it is decocted or swallowed，only a few pesticides in Ginseng Radix et Rhizoma can be dissolved，and the content of dissolution is very limited, dissolution rates are lower than 12%. Especially in the decoction, the most commonly used method of Traditional Chinese Medicines, the dissolution rates of three pesticides were all less than 1%, suggesting that the particularity of Traditional Chinese Medicines should be fully taken into account when evaluating the risk assessment of pesticide residues. Taking Ginseng Radix et Rhizoma as an example, this study conducted a preliminary study on the dissolution of pesticide residues in Traditional Chinese Medicines under two medication methods in order to provide ideas and basic data for setting standards of pesticide residues in Traditional Chinese Medicines. |
| keywords:pesticide residue decoction artificial gastrointestinal fluid dissolution rate |
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