止泻木子中锥丝碱的提取工艺
投稿时间:2018-10-26     点此下载全文
引用本文:郑光杰,邱娜,刘凡凡,晋敦青,孙博航.止泻木子中锥丝碱的提取工艺[J].中国现代中药,2018,20(12):1544-1548
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作者中文名作者英文名单位中文名单位英文名E-Mail
郑光杰 ZHENG Guang-jie 沈阳药科大学 中药学院/基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 School of Key Laboratory of Structure Based Drug Design & Discovery of Ministry of Education,School of Tradition Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016
China
 
邱娜 QIU Na 沈阳药科大学 中药学院/基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 School of Key Laboratory of Structure Based Drug Design & Discovery of Ministry of Education,School of Tradition Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016
China
 
刘凡凡 LIU Fan-fan 郑州市中心医院 药学部,河南郑州467000 Zhengzhou Central Hospital Pharmacy Department,Zhengzhou 467000,China  
晋敦青 JIN Dun-qing 沈阳药科大学 中药学院/基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110017 School of Key Laboratory of Structure Based Drug Design & Discovery of Ministry of Education,School of Tradition Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016
China
 
孙博航 SUN Bo-hang 沈阳药科大学 中药学院/基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110018 School of Key Laboratory of Structure Based Drug Design & Discovery of Ministry of Education,School of Tradition Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110017
China
孙博航,副教授,研究方向:天然药物化学成分的分离纯化;Tel:(024)23986482,E-mail:sunbohang1978@163.com 
基金项目:辽宁省教育厅科学技术研究项目(201610163120)
中文摘要:目的:优化止泻木子中锥丝碱的提取工艺,为止泻木子质量控制标准的建立奠定基础。方法:在单因素试验基础上,以提取时间、甲醇浓度、料液比为因素,以止泻木子中锥丝碱提取得率为响应值,采用三因素三水平响应曲面试验设计法,确定最佳提取工艺。结果:最佳提取工艺为提取时间70 min、甲醇浓度75%、料液比1∶9。结论:该提取工艺稳定、合理、预测性良好。
中文关键词:止泻木子  锥丝碱  响应曲面  提取工艺  高效液相色谱法
 
Study on Extraction Technology of Conessine from Holarrhena antidysenteriaca
Abstract:Objective:The process of extracting conessine from Holarrhena antidysenteriaca optimized for establishing the quality control standards of Holarrhena antidysenteriaca.Methods: Based on the results of single factor tests,we selected extraction time,methanol concentration and solid/liquid ratio as the experimental factors and used the extraction yield of conessine from as the response value.Results:The optimal extraction parameters were as follows: extraction time 70 min,methanol concentration 75%,solid/liquid ratio 1:9.Conclusion:The extraction method is reliable,reasonable and highly predictable.
keywords:Holarrhena antidysenteriaca  conessine  response surface method  extraction technology
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