大白杜鹃的化学成分研究 |
投稿时间:2019-01-19 点此下载全文
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引用本文:历明辉,陈新涛,吕光辉,陈黎.大白杜鹃的化学成分研究[J].中国现代中药,2019,21(8):1021-1024 |
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基金项目:湖北省卫生和计划生育委员会科研项目(WJ2017F079);2017度太和医院软科学项目计划(2017rkt12);2018年太和医院院级项目(2018JJXM111) |
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中文摘要:目的:探索大白杜鹃Rhododendron decorum枝叶结构新颖的化学成分。方法:反复利用正相硅胶、ODS、MCI、Sephadex LH-20等柱色谱以及半制备HPLC等分离手段对大白杜鹃95%的乙醇水提取物进行分离纯化,并根据其谱学数据、理化性质进行结构鉴定。结果:从大白杜鹃枝叶的95%乙醇水提取物中分离鉴定了8个化合物,包括2个木脂素和2个苯丙素类物质,3个倍半萜和1个降倍半萜,分别是(7 S,8 S)-3-甲氧基-3′,7-环氧-8,4′-氧代新木脂素-4,9,9′-三醇(1)、(+)-8-羟基松脂醇(2)、异阿魏酸(3)、二氢紫丁香苷(4)、山楂叶苷元B(5)、反烷-4(15)-烯-1β,11-二醇(6)、1,10-裂环-4-羟基-衣兰醇-5-烯-1,10-二酮(7)、(-)-黑麦草内酯(8)。结论:化合物1~8均为首次从大白杜鹃中分离得到。 |
中文关键词:大白杜鹃 木脂素 苯丙素 倍半萜 |
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Chemical Constituents isolated from Rhododendron decorum |
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Abstract:Objective:To investigate the structurally unique chemical constituents of Rhododendron decorum.Methods:Compounds were isolated by methods of column chromatography(silica gel,ODS,Sephadex LH-20),their structures were confirmed on the basis of physicochemical properties and spectroscopic methods.Results:Eight known compounds,including two lignans,two phenylpropanoids and four sesquiters were isolated from 95% EtOH extracts of Rh.decorum and identified as(7 S,8 S)-3-methoxy-3′,7-epoxy-8,4′-oxyneoligna-4,9,9′-triol(1),(+)-8-hydroxypinoresinol(2),isoferulic acid(3),dihydrosyringenin(4),shanyegenin B(5),opposit-4(15)-en-1β,11-diol(6),1,10-seco-4-hydroxy-muurol-5-ene-1,10-diketone(7),(-)-loliolide(8).Conclusion:The eight known compounds were isolated from this genius for the first time. |
keywords:Rhododendron decorum lignans phenylpropanoid sesquiterpene |
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