正交试验、响应面法优化加味三根汤的提取工艺比较 |
投稿时间:2019-01-07 点此下载全文
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引用本文:李华妮,郑连营,葛文静,王艳艳,刘长河.正交试验、响应面法优化加味三根汤的提取工艺比较[J].中国现代中药,2019,21(8):1089-1093 |
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基金项目:河南科技攻关项目(2017ZY0506) |
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中文摘要:目的:优选加味三根汤水提工艺。方法:以提取总皂苷的含量为指标,采用正交设计法和响应面法对提取次数、提取时间和液料比等条件进行优化,确定最优提取工艺。结果:正交设计法分析的最佳提取工艺为液料比10∶1,提取2次,每次1.5 h,总皂苷的质量分数为2.90 mg·g-1;响应面法分析的最优工艺为液料比8∶1,提取2次,每次2 h。总皂苷的质量分数为3.21 mg·g-1。结论:两种方法生产耗能基本相同,但响应面法提取的总皂苷含量比正交试验法提高了10.7%,更适合加味三根汤提取工艺。 |
中文关键词:加味三根汤 正交试验 响应面法 总皂苷 |
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Comparison of Extraction Process of Jiawei Sangen Decoction Optimized by Orthogonal Experiment and Response Surface Methodology |
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Abstract:Objective:To optimize water extraction process for the preparation of Jiaweisangen Decoction.Methods:The total saponin was selected as an indicator,the factors including extraction times,extraction time and the liquid to material ratio were investigated by means of orthogonal experiment and response surface methodology,recpectively.Results:The extraction conditions optimized with orthogonal experiment for total saponin was extraction times of two,extraction time of 1.5 h,liquid to material ratio of 10∶1 and the total saponin content was 2.90 mg·g-1.The optimized process from response surface methodology was extraction times of two,extraction time of 2 h,liquid to material ratio of 8∶1 and the total saponin content was 3.21 mg·g-1.Conclusion:The two methods consume the same amount of energy,but the total saponin content extracted by the response surface methodology has increased by 10.7 % compared with orthogonal experiment,is more suitable for the extraction process of Jiaweisangen decoction. |
keywords:Jiawei Sangen decoction orthogonal experiment response surface methodology total saponin |
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