Determination and Evaluation of Powder Properties of Naoxintong Capsule Filler
Abstract:Objective:To determine and evaluate the powder properties of Naoxintong capsule filler.Methods:Powder properties such as fluidity,hygroscopicity,particle size and particle size distribution of Naoxintong capsule fillings were studied by using powder comprehensive characteristic tester,wettability test and laser particle size analyzer.Results:The angle of repose of Naoxintong capsule filler was close to 60°,the compression was greater than 0.5,the uniformity was close to 8,and the Carr fluidity index reached 43,indicating that the fluidity of the material was poor.The Naoxintong capsule filling has hygroscopicity with a critical relative humidity of 75%.The optimized conditions for the laser particle size analyzer were as follows:dispersion pressure was 2.5 bar,feed rate was 60%,hopper clearance was 2 mm,sample loading was 1.0 g and detection time was 20 s.The particle sizes D(3,2),D(4,3)were(33.33±1.48)μm and(105.34±4.35)μm,respectively;and the particle size distribution d10,d50 and d90 were(13.13±0.59)μm,(71.95±2.06)μm,and(231.80±10.56)μm,respectively.Conclusion:The research on the powder properties of Naoxintong capsule filer provided a reference for the management control and quality inspection of Naoxintong capsule during the production process.