| GC测定香砂养胃丸中乙酸龙脑酯、龙脑及樟脑的含量 |
| 投稿时间：2018-11-12 点此下载全文
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| 引用本文：程雅婷,王晓云,王学涛,王艳博,庞静,刘凯娜,郑斓.GC测定香砂养胃丸中乙酸龙脑酯、龙脑及樟脑的含量[J].中国现代中药,2019,21(8):1114-1117 |
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| 中文摘要:目的：GC测定香砂养胃丸中乙酸龙脑酯、龙脑和樟脑的含量，以控制药品的有效性。方法：ACQUITY Agilent Technologies，Inc.DB-1（30 m×0.320 mm，0.50 μm）色谱柱，载气：氮气，流速4.0 mL·min-1，进样量：1 μL，进样方式：分流进样，分流比：10∶1，进样口温度：230 ℃，梯度升温程序：初始温度：60 ℃，5 ℃·min-1升温至130 ℃，保持5 min，20 ℃·min-1升温至230 ℃，保持5 min。检测器：FID检测器，检测器温度：280 ℃。结果：乙酸龙脑酯、龙脑、樟脑3种成分分别在0.807 3～322.903 2、0.647 6～259.036 8、1.014 1～405.657 0 ng线性关系良好，精密度、稳定性、重复性RSD均低于3.0%，平均加样回收率分别为83.54%（RSD=2.82%）、98.23%（RSD=2.78%）、87.07%（RSD=3.01%）。结论：该方法准确、可靠，可用于香砂养胃丸中3种成分的含量测定。 |
| 中文关键词:香砂养胃丸 乙酸龙脑酯 龙脑 樟脑 砂仁 气相色谱法 |
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| Determination of Bornyl Acetate，Borneol and Camphor in Xiangsha Yangwei Pills by GC |
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| Abstract:Objective：To establish a method using GC to measure bornyl acetate，borneol and camphor in Xiangshayangwei pills for effectiveness control.Methods：Agilent DB-1（30 m×0.320 mm，0.50 μm）chromatographic column was used for detection，carrier gas was nitrogen at a flow rate of 4.0 mL·min-1.The injection volume was 1 μL and the split ratio was 10∶1.The inlet temperature was 230 ℃，the initial column temperature was 60 ℃ and was programmed at 5 ℃·min-1 to 130 ℃ and held for 5 min，then at 20 ℃·min-1 to 230 ℃ and held for 5 min.The detector was FID at 280 ℃.Results：The linear relationship were all good when bornyl acetate was 0.807 3-322.903 2 ng，borneol was 0.647 6-259.036 8 ng and camphor was 1.014 1-405.657 0 ng.The RSD on precision，stability and repeatability were all below 3.0%，sample recovery rates were 83.54%（RSD=2.82%），98.23%（RSD=2.78%）and 87.07%（RSD=3.01%）.Conclusion：The proposed method was accurate and reliable，it can be used in the measuring bornyl acetate、borneol and camphor in Xiangshayangwei pills. |
| keywords:Xiangsha Yangwei pills bornyl acetate borneol camphor Fructus Amomi GC |
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