Abstract:Gekko gecko,a precious Chinese medicine,has been used for treating diseases for thousands years in China.In this paper,we summarized and teased out the ancient bencao works on the distribution,origin,collection and processing,nature and taste,efficacy and treatment of the gecko to clarify the historical records and modern documents of the gecko.This paper puts forward a reasonable explanation for the differences in the toxicity of gecko found in the research,and provides a herbalism basis for the clinical application and scientific research of the gecko.