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作者中文名	作者英文名	单位中文名	单位英文名	E-Mail
赵秋龙	ZHAO Qiu-long	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China
卞晓坤	BIAN Xiao-kun	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China
钱大玮	QIAN Da-wei	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China	钱大玮，研究员，研究方向：中药产地加工和质量控制研究；Tel：（025）85811916，E-mail：qiandwnj@126.com
张丽	ZHANG Li	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China
陈菲菲	CHEN Fei-fei	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China
郭盛	GUO Sheng	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China
严辉	YAN Hui	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China
王团结	WANG Tuan-jie	江苏康缘药业股份有限公司，江苏连云港222001	Kanion Pharmaceutical Co.，Ltd.，Lianyungang 222001，China
赵建军	ZHAO Jian-jun	宁夏医科大学药学院，宁夏银川750004	College of Pharmacy，Ningxia Medical University，Yinchuan 750004，China
段金廒	DUAN Jin-ao	南京中医药大学江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室/中药资源产业化与方剂创新药物国家地方联合工程研究中心，江苏南京210023	Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of TCM Formulae/National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine，Nanjing University of Chinese Medicine，Nanjing 200023，China

基金项目:国家中药标准化项目（ZYBZH-C-JS-28）；宁夏回族自治区重点研发计划（东西部科技合作）项目（2017BY079）

中文摘要:目的：研究不同干燥方法对牡丹皮药材化学成分的影响。方法：采收牡丹皮新鲜药材，分别采用3种现代不同干燥方式（热风、红外、微波）下4个不同干燥温度（40、50、60、70 ℃）及晒干、阴干处理，干燥至水分合格为止；采用超高效液相色谱-三重四级杆质谱串联法（UPLC-TQ-MS）技术，对牡丹皮中酚及酚苷类、单萜苷类、有机酸类、黄酮类、鞣质类、苯丙素类等类型共16个成分进行含量测定。将14个干燥品的分析结果标准化处理，进行主成分（PCA）分析。结果：经主成分分析，不同干燥方法处理的牡丹皮药材中化学成分含量综合评分依次为：红外（40 ℃）干燥＞红外（50 ℃）干燥＞微波（60 ℃）干燥＞红外（60 ℃）干燥＞微波（40 ℃）干燥＞热风（50 ℃）干燥＞微波（50 ℃）干燥＞热风（40 ℃）干燥＞红外（70 ℃）干燥＞微波（70 ℃）干燥＞热风（60 ℃）干燥＞热风（70 ℃）干燥＞阴干＞晒干。结论：不同干燥方法对牡丹皮药材中各类化学成分有一定影响，牡丹皮药材干燥方法以红外（40 ℃）干燥处理为宜。

中文关键词:牡丹皮干燥方法主成分分析含量变化

Effects of Different Drying Methods on Chemical Composition Changes of Cortex Moutan

Abstract:Objective：The present study was designed to evaluate the effects of different drying methods on chemical composition of Cortex Moutan.Method：The fresh Cortex Moutan was processed with four different drying methods （40 ℃，50 ℃，60 ℃ and 70 ℃） under three different drying methods （hot air，infrared，microwave），shade dried and sun dried until the contented water met the requirments.UPLC-TQ/MS technology was used to determine the content of 16 components （phenolic glycosides，monoterpenoid glycosides，organic acids，flavonoids，tannins and phenylpropanoids） in Cortex Moutan.The principal component analysis（PCA） was made on the standardized analysis results for the 14 groups of samples processed with different drying methods.Results：According to the PCA results，the comprehensive scores of chemical composition Cortex Moutan processed with different methods in the order from high to low were that dried with infrared at 40 ℃＞dried with infrared at 50 ℃＞dried with microwave at 60 ℃＞dried with infrared at 60 ℃＞dried with microwave at 40 ℃＞dried with hot air at 50 ℃＞dried with microwave at 50 ℃＞dried with hot air at 40 ℃＞dried with infrared at 70 ℃＞dried with microwave at 70 ℃＞dried with hot air at 60 ℃＞dried with hot air at 70 ℃＞shade dried＞sun dried.Conclusion：According to the findings，different drying methods have certain impacts on chemical composition of Cortex Moutan.The suitable method for Cortex Moutan drying is drying with infrared at 40 ℃.

keywords:Cortex Moutan drying methods PCA composition changes

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