基于近红外光谱技术的砂仁提取物混合工艺研究
投稿时间:2018-12-27     点此下载全文
引用本文:刘燎原,梁志毅,刘丽萍,钟如帆.基于近红外光谱技术的砂仁提取物混合工艺研究[J].中国现代中药,2020,22(1):85-88
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作者中文名作者英文名单位中文名单位英文名E-Mail
刘燎原 LIU Liao-yuan 广东一方制药有限公司,广东佛山528244 Guangdong Yifang Pharmaceutical Co.,Ltd.,Foshan 528244,China  
梁志毅 LIANG Zhi-yi 广东一方制药有限公司,广东佛山528244 Guangdong Yifang Pharmaceutical Co.,Ltd.,Foshan 528244,China 梁志毅,中药执业药师,研究方向:中药配方颗粒;E-mail:liangzy112@163.com 
刘丽萍 LIU Li-ping 广东一方制药有限公司,广东佛山528244 Guangdong Yifang Pharmaceutical Co.,Ltd.,Foshan 528244,China  
钟如帆 ZHONG Ru-fan 广东一方制药有限公司,广东佛山528244 Guangdong Yifang Pharmaceutical Co.,Ltd.,Foshan 528244,China  
基金项目:广东特支计划科技创业领军人才项目(2017TY04R197);广东省科协2018年度创新能力提升项目(粤科标【2018】7号)
中文摘要:目的:采用近红外光谱技术(NIRS)建立砂仁提取物混合物中砂仁挥发油β-环糊精包合物的定量模型,并优化砂仁提取物混合工艺。方法:以砂仁挥发油β-环糊精包合物含量为真实值,运用偏最小二乘(PLS)法建立NIRS与砂仁挥发油β-环糊精包合物含量之间的定量校正模型,并对混合工艺进行优选。结果:所建NIRS定量模型r=0.995 5,交互验证误差均方根(RMSECV)为0.383,验证集平均预测回收率为98.22%,表明该模型预测能力较好;砂仁提取物混合物不同部位中挥发油β-环糊精包合物含量测定的RSD分别为2.48%、3.42%、2.25%,均小于5.0%,表明混合均匀,确定砂仁提取物的混合工艺为:混合转速5 r·min-1,混合时间20 min。结论:NIRS技术可用于砂仁提取物混合工艺的检测与评价。
中文关键词:近红外光谱  砂仁  挥发油β-环糊精包合物  混合工艺
 
Researchon Mixing Process of Amomum Villosum Extract Based on Near Infrared Spectroscopy
Abstract:Objective:To establish a quantitative model of Amomum Villosum volatile oil β-cyclodextrin (β-CD) inclusion compound of Amomum villosum extract mixture by using near infrared spectroscopy (NIRS),and optimize the mixing process of Amomum villosum extract. Methods:Taking the actual content of Amomum Villosum volatile oil inclusion compound as the true value,the quantitative correction model between NIRS and Amomum Villosum volatile oil β-CD inclusion compound content was established by partial least squares (PLS) method,and the mixing process was optimized.Results:The correlation coefficient (r) of the established NIRS quantitative model was 99.55%,the root mean square (RMSECV) of the interactive verification error was 0.383,and the average prediction recovery rate of the verification set was 98.22%,indicating that the model had good prediction ability.The RSD values of volatile oil β-CD inclusion compounds in different parts of Amomum Villosum extract mixture were 2.48%,3.42% and 2.25% respectively,all less than 5.0%,indicating that when Amomum Villosum extract was mixed at 5 r·min-1,the mixture was almost evenly mixed at 20 min.Conclusion:NIRS technology can be used to detect and evaluate the mixing process of Amomum Villosum extract.
keywords:near infrared spectroscopy  Amomum Villosum  volatile oil β-CD inclusion compound  the mixing process
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