阿魏酸的研究进展
投稿时间:2019-03-11     点此下载全文
引用本文:张欣,高增平.阿魏酸的研究进展[J].中国现代中药,2020,22(1):138-147
DOI:
摘要点击次数: 52
全文下载次数: 0
     
作者中文名作者英文名单位中文名单位英文名E-Mail
张欣 ZHANG Xin 北京中医药大学 中药学院,北京102488 School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China  
高增平 GAO Zeng-ping 北京中医药大学 中药学院,北京102488 School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China 高增平,博士生导师,教授,研究方向:中药有效物质基础及质量控制研究;E-mail:gaozp@bucm.edu.cn 
中文摘要:阿魏酸及其衍生物的药用价值越来越受到重视,笔者通过系统梳理阿魏酸在来源、药理作用、安全性及临床应用4个方面近30年来的研究文献,总结其研究进展如下:1)来源包括天然来源、化学合成和生物合成;2)已发现的药理作用有抗氧化、抗血栓、降血脂、降低心肌缺血和耗氧量、抗菌、抗病毒、抗癌等;3)体外无细胞毒性作用,只抑制细胞增殖,体内与川芎嗪在半数致死量下,共同作用毒性可降低,且其毒性有随季节变化的趋势;4)临床上多用于治疗冠心病、肾病、肺动脉高压、脑梗死、阿尔茨海默病等疾病。此综述旨在为更好地开发利用阿魏酸及其衍生物提供参考。
中文关键词:阿魏酸  药理作用  安全性  临床应用
 
Research Progress in Ferulic Acid
Abstract:The medicinal value of ferulic acid and its derivatives has attracted more and more attention.The author systematically reviewed the research literature of ferulic acid in the past 30 years in terms of its source,pharmacological action,safety and clinical application,and summarized the research progress:1) sources include natural sources,chemical synthesis and biosynthesis;2) the pharmacological effects have been found to be antioxidant,antithrombotic,hypolipidemic,reducing myocardial ischemia and oxygen consumption,antibacterial,antiviral,anticancer,etc;3) there was no cytotoxic effect in vitro,only the proliferation of cells was inhibited.In vivo,the combined toxicity with ligustrazine could be reduced under the lethal dose of half,and the toxicity showed a trend of seasonal changes;4) clinically,it is mainly used to treat coronary heart disease,kidney disease,pulmonary hypertension,cerebral infarction,Alzheimer′s disease and other diseases.This review is intended to provide a reference for the better development and utilization of ferulic acid and its derivatives.
keywords:ferulic acid  pharmacological action  safety  clinical application
查看全文   查看/发表评论  下载PDF阅读器