苏龙嘎-4颗粒抗炎 镇痛 止泻的药效学实验研究
投稿时间:2019-09-20     点此下载全文
引用本文:陈影,苏萍,张广平,张海静,杨依霏,陈腾飞,马丽娜,侯红平,高云航,李晗,张钟秀,叶祖光.苏龙嘎-4颗粒抗炎 镇痛 止泻的药效学实验研究[J].中国现代中药,2020,22(4):552-557
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作者中文名作者英文名单位中文名单位英文名E-Mail
陈影 CHEN Ying 辽宁师范大学 生命科学学院,辽宁大连116000 College of Life Science,Liaoning Normal University,Dalian 116000,China  
苏萍 SU Ping 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
张广平 ZHANG Guang-ping 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
张海静 ZHANG Hai-jing 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
杨依霏 YANG Yi-fei 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
陈腾飞 CHEN Teng-fei 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
马丽娜 MA Li-na 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
侯红平 HOU Hong-ping 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
高云航 GAO Yun-hang 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
李晗 LI Han 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
张钟秀 ZHANG Zhong-xiu 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China  
叶祖光 YE Zu-guang 中国中医科学院 中药研究所,北京100075 Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences,Beijing 100075,China 叶祖光,博士生导师,研究员,研究方向:中药药理毒理研究;Tel:(010)84252805,E-mail:zgye@icmm.ac.cn 
基金项目:国家“重大新药创制”重大专项(2017ZX09301060-013)
中文摘要:目的:验证苏龙嘎-4颗粒涩肠、止泻、抗炎及镇痛功效。方法:小鼠按体质量随机分组,灌胃给予苏龙嘎-4颗粒,剂量(以生药计)分别为:0.16、0.33、0.65、1.30 g ·kg-1。采用炭末推进实验对苏龙嘎-4颗粒进行涩肠作用研究;以粪便观察法对苏龙嘎-4颗粒进行止泻作用研究;以二甲苯致小鼠耳肿胀实验对苏龙嘎-4颗粒进行抗炎作用研究;以醋酸扭体实验对苏龙嘎-4颗粒进行镇痛作用研究。结果:与空白组比较,苏龙嘎-4颗粒能缩短炭末在正常小鼠肠道内的推进距离(P<0.01),降低炭末推进率(P<0.05,P<0.01);与模型组比较,苏龙嘎-4颗粒能缩短炭末在蓖麻油所致腹泻小鼠肠道内的推进距离(P<0.001),降低炭末推进率(P<0.01,P<0.001);能减少蓖麻油致小鼠腹泻的稀便数(P<0.05,P<0.01);对硫酸镁致小鼠腹泻无显著抑制作用(P>0.05);能减少番泻叶致小鼠腹泻的稀便数(P<0.01);能减少扭体次数(P<0.05,P<0.01,P<0.001),提高扭体抑制率;能明显降低小鼠耳肿胀率(P<0.01,P<0.001)。结论:苏龙嘎-4颗粒具有明显的涩肠、止泻、抗炎及镇痛作用,值得进一步研发和推广。
中文关键词:苏龙嘎-4颗粒  药效  涩肠  止泻  抗炎  镇痛
 
Experimental Study on Anti-inflammatory,Analgesic and Antidiarrheal Effects of Sulongga-4 Granules
Abstract:Objective:To verify the effect of Sulongga-4 granules on the intestines,diarrhea,anti-inflammatory and analgesic effects.Methods:Mice were randomly divided into groups according to body weight. Sulongga-4 particles were intragastrically administered at doses raw medicine of 0.16,0.33,0.65 and 1.30 g·kg-1,respectively. The astringent effect of Sulongga-4 granules was studied by carbon powder propulsion test,the anti-diarrhea effect of Sulongga-4 granules was studied by fecal observation method,the analgesic effect of Sulongga-4 granules was studied by acetic acid writhing test,and the anti-inflammatory effect of Sulongga-4 granules was studied by xylene-induced ear swelling test.Results:Compared with the blank group,Sulongga-4 granules could shorten the advancement distance of carbon in the intestinal tract of normal mice (P<0.01),reduce charcoal propulsion rate(P<0.05,P<0.01). Compared with the model group,Sulongga-4 particles could shorten carbon. The propulsion distance in the intestine of mice with diarrhea caused by castor oil (P<0.01,P<0.001);the number of loose stools caused by castor oil in mice with diarrhea (P<0.05,P<0.01);the diarrhea caused by magnesium sulfate was not significant Inhibition (P>0.05);can reduce the number of loose stools caused by senna-induced diarrhea in mice (P<0.01);can reduce the number of writhing (P<0.05,P<0.01,P<0.001),improve the twist Body inhibition rate;can significantly reduce the swelling rate of mouse ears (P<0.01,P<0.001).Conclusion:Sulongga-4 granules have obvious effects on calf,diarrhea,anti-inflammatory and analgesic,which deserve further research and development.
keywords:Sulongga-4 granules  efficacy  astringent intestine  anti-diarrhoea  anti-inflammation  analgesia
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