| 潜阳封髓丹对化疗致口腔黏膜炎的作用研究 |
| 投稿时间：2019-10-16 点此下载全文
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| 引用本文：唐晓丽,杨霖,刘悦,牛芬溪,方芳.潜阳封髓丹对化疗致口腔黏膜炎的作用研究[J].中国现代中药,2020,22(4):558-563 |
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| 基金项目:北京市自然科学基金（7174312） |
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| 中文摘要:目的：研究潜阳封髓丹对化疗致金黄地鼠口腔黏膜炎的作用。方法：采用5-氟尿嘧啶（5-FU）联合机械划伤进行造模，潜阳封髓丹分为低、中、高剂量进行给药。每天记录体质量和进食量，对金黄地鼠口腔颊囊进行宏观观察并拍照评分，苏木精-伊红（HE）染色观察口腔颊囊组织的病理损伤。酶联免疫吸附反应（ELISA）测定金黄地鼠血清中促炎症因子肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β） 的含量，生化试剂盒测定金黄地鼠口腔颊囊组织中的超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量。结果：潜阳封髓丹给药能降低动物口腔颊囊宏观评分，改善口腔颊囊的病理损伤，减轻炎症状况，降低金黄地鼠血清中TNF-α、IL-1β和口腔颊囊组织中MDA的含量。结论：潜阳封髓丹用药对金黄地鼠口腔黏膜炎有一定的缓解作用，促进病理损伤愈合，可能与降低炎症反应和氧化损伤有关。 |
| 中文关键词:潜阳封髓丹 口腔黏膜炎 金黄地鼠 炎症 氧化应激 |
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| Effect of Qianyang Fengsuidan on Oral Mucositis Caused by Chemotherapy |
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| Abstract:Objective：To study the effect of Qianyang Fengsui Dan on oral mucositis caused by chemotherapy in golden hamster.Methods：Oral mucositis was induced by 5-FU combined with mechanical scratching.The Qianyang Fengsui Dan (low，medium and high doses) were administered to the golden hamster once a day for 14 day.Body weight and food intake were recorded daily.Pathological changes were observed by HE staining and macroscopic scores.The contents of TNF-α and IL-1β in the serum of golden hamster were determined by ELISA.The SOD activity and MDA content in the cheek pouch tissue of golden hamster was determined by biochemical kit.Results：The application of Qianyang Fengsui Dan was capable to reduce the macroscopic score of oral cheek pouch tissue and the content of TNF-α，IL-1β and MDA，and improve the pathological damage of golden hamster.Conclusion：Qianyang Fengsui Dan can relieve the oral mucositis of golden hamster and promote the healing of pathological injury，which is related with anti-inflammation and anti-oxidation. |
| keywords:Qianyang Fengsuidan oral mucositis golden hamster inflammation lipid peroxide |
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