不同干燥工艺对药用大黄功效组分的影响
投稿时间:2019-11-16     点此下载全文
引用本文:丁一明,商彤,石玥,赵婷,张媛,李莉,魏胜利.不同干燥工艺对药用大黄功效组分的影响[J].中国现代中药,2020,22(4):591-595
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作者中文名作者英文名单位中文名单位英文名E-Mail
丁一明 DING Yi-ming 北京中医药大学 中药学院,北京102488 School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 102488,China  
商彤 SHANG Tong 北京中医药大学 中药学院,北京102488 School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 102488,China  
石玥 SHI Yue 北京中医药大学 中药学院,北京102488 School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 102488,China  
赵婷 ZHAO Ting 北京中医药大学 中药学院,北京102488 School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 102488,China  
张媛 ZHANG Yuan 北京中医药大学 中药学院,北京102488 School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 102488,China  
李莉 LI Li 首都医科大学 附属北京中医医院,北京100010 Beijing Chinese Medicine Hospital Affiliated to Capital Medical University,Beijing 100010,China  
魏胜利 WEI Sheng-li 北京中医药大学 中药学院,北京102488 School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing 102488,China 魏胜利,教授,研究方向:中药资源定向培育及中药资源综合开发;Tel:(010)84738334,E-mail:wsl7491@126.com 
基金项目:国家自然科学基金项目(31570331,31170307);国家重点研发计划项目(2017YFC1700702);北京中医药大学自主课题(2019-JYB-XS-087)
中文摘要:目的:确定不同功效型大黄的干燥工艺。方法:采用HPLC分别测定药用大黄中鞣质类、二蒽酮类、游离蒽醌类及结合蒽醌类成分的含量,并用双因素方差分析的方法对结果进行分析。结果:不同干燥工艺条件下,药用大黄中鞣质类、二蒽酮类、游离蒽醌类、结合蒽醌类成分含量差异有统计学意义。以鞣质类含量为指标,根茎最适宜干燥条件为切1 cm厚、60 ℃干燥,根为切1 cm厚、30 ℃干燥;以二蒽酮类含量为指标,根茎最适宜干燥条件为切1 cm厚、60 ℃干燥,根为切5 cm厚、40 ℃干燥;以游离蒽醌类含量为指标,根茎最适宜干燥条件为切3 cm厚、50 ℃干燥,根为切3 cm厚、30 ℃干燥;以结合蒽醌类含量为指标,根茎最适宜干燥条件为切5 cm厚、40 ℃干燥,根为切5 cm厚、70 ℃干燥。结论:不同功效组分型大黄的定向加工方式不同,可以通过降低干燥温度或增加切片厚度的干燥工艺,定向加工泻下攻积型大黄;通过提高干燥温度或减小切片厚度的干燥工艺,定向加工出清热泻火型大黄。
中文关键词:药用大黄  干燥工艺  功效组分
 
Effects of Different Drying Processes on Effective Components of Rheum officinale
Abstract:Objective:To determine the drying process of different functional rhubarbs. Methods:The contents of tannins,bianthrone,free anthraquinones and combined anthraquinones in medicinal rhubarb were determined by HPLC. The results were analyzed by two-way analysis of variance. Results:Under different drying conditions,the contents of tannins,bianthrone,free anthraquinones and combined anthraquinones in medicinal rhubarb were significantly different. Taking the tannins content as the index,the optimum drying condition of the rhizome is 1 cm thick,dried at 60 ℃,the root is cut 1 cm thick,and dried at 30 ℃;the bianthrone content is used as an indicator,the rhizome is optimally dried. The condition is to cut 1 cm thick,dry at 60 ℃,the root is cut to 5 cm thick,and dried at 40 ℃;the free anthraquinones content is used as an index,and the optimum drying condition of the rhizome is 3 cm thick and dried at 50 ℃. The root is cut to a thickness of 3 cm and dried at 30 ℃. The combine anthraquinones content is used as an indicator. The optimum drying conditions for the rhizome are 5 cm thick,dried at 40 ℃,and the root is cut to 5 cm thick and dried at 70 ℃. Conclusion:The functional components of rhubarb have different directional processing methods. The drying process can reduce the drying temperature or increase the thickness of the slice,and the directional processing of the diarrhea-type rhubarb can be processed. The drying process can be carried out by increasing the drying temperature or reducing the thickness of the slice directed processing of heat-clearing and purging-fire rhubarb.
keywords:Rheum officinale Baill.  drying methods  functional components
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