| 基于实体语法系统解析解郁丸的药理学作用机制 |
| 投稿时间：2019-09-06 点此下载全文
|
| 引用本文：侯旭粲,成思凡,任兴德,李梦,王耘.基于实体语法系统解析解郁丸的药理学作用机制[J].中国现代中药,2020,22(7):1056-1065 |
| DOI： |
| 摘要点击次数: 540 |
| 全文下载次数: 204 |
|
|
| 基金项目:国家自然科学基金项目（81673697） |
|
| 中文摘要:目的：抑郁症是一种严重影响人们正常生活的疾病，对人们的精神世界和身体健康构成了双重威胁。解郁丸是基于中医理论和长期实践的抗抑郁配方，已被证明具有良好的抗抑郁和抗失眠效果，但解郁丸的药理学作用机制及其化学成分在人体中的作用范围尚不明确，导致其应用受到一定程度的限制，希望通过本研究促进解郁丸的应用。方法：本研究以“TCM语法系统”和实体语法系统为基础，运用网络药理学方法，以获得解郁丸的化学成分作用的抑郁症相关基因；然后根据筛选规则，获得这些基因在细胞中的表达数据、细胞的器官和组织定位数据。结果：笔者得到了解郁丸化学成分通过直接作用于9个和间接作用于11个抑郁症相关基因来治疗抑郁症；随后筛选出了可以表达这些基因的细胞，获得了解郁丸成分作用的组织和器官，给出了解郁丸的化学成分在人体中的作用范围和对免疫组织的特异性作用。结论：总之，通过分析结果，笔者提出解郁丸可以在抗抑郁的同时调节机体的免疫功能，并且具有治疗抑郁症和其他疾病的合并症的潜能。 |
| 中文关键词:抑郁症 解郁丸 蛋白质表达 细胞 |
| |
| Analysis of Pharmacological Mechanism of Jieyu Pill Based on Entity Grammar System |
|
|
| Abstract:Objective：Depression is a disease that seriously affects people′s normal life and poses a double threat to people′s spiritual world and physical health. Jieyu Pill is an formula based on traditional Chinese medicine theory and long-term practice，it has been proven to have good antidepressant and anti insomnia effects. However，The pharmacological mechanism of Jieyu Pill and the action scope of its chemical components are still uncertain，which leads to the limited application of it to some extent，and we hope to promote the application of it through this study. Methods：Based on the ″TCM grammar system″ and Entity Grammar System，the network pharmacology method is used to obtain the depression-related genes that chemical components of Jieyu Pill can act on，subsequently，according to the screening rules，the expression situation of depression-related genes in some cells and the organs or tissues localization of these cells can be obtained. Results：The chemical components of Jieyu Pill could treat depression by directly acting on 9 and indirectly acting on 11 depression-related genes，besides，cells that can express these genes were screened，tissues and organs that chemical components can act were obtained. Finally，the result that the action range of chemical components and the specific effects on immune tissues were provided. Conclusion：In summary，by analyzing the results，we proposed that not only can Jieyu Pill regulate the immune function of body while anti depression，but also did it has the potential to treat comorbidities of depression and other diseases. |
| keywords:depression Jieyu Pill protein expression cells |
|
查看全文
查看/发表评论 下载PDF阅读器 |
