| 基于网络药理学的甘草治疗溃疡性结肠炎作用机制研究 |
| 投稿时间：2020-03-07 点此下载全文
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| 引用本文：李晴霞,康念欣,袁炎炎,刘永刚,谭鹏.基于网络药理学的甘草治疗溃疡性结肠炎作用机制研究[J].中国现代中药,2021,23(3):464-469 |
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| 基金项目:国家“重大新药创制”科技重大专项（2020071620211） |
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| 中文摘要:目的：采用网络药理学方法探讨甘草治疗溃疡性结肠炎的作用机制。方法：通过中药系统药理学数据库与分析平台（TCMSP）筛选甘草的活性成分并检索出活性成分的作用靶点；通过CTD数据库查询与溃疡性结肠炎相关的靶点；采用UniProt数据库、Cytoscape 3.7.2软件构建成分-靶点、靶点蛋白相互作用和成分-靶点-生物学通路网络。结果：通过筛选，得到甘草中92个活性成分，相应靶点227个，其中与溃疡性结肠炎相关的靶点41个，主要包括肿瘤坏死因子（TNF）、白细胞介素-6（IL-6）、丝裂原活化蛋白激酶3（MAPK3）、血管内皮生长因子A（VEGFA）等；这41个靶点主要涉及IL-17、阿米巴病、炎症性肠病等28条生物学通路。结论：甘草治疗溃疡性结肠炎是多成分、多靶点、多途径相互作用的结果，为其进一步深入研究提供参考。 |
| 中文关键词:甘草 溃疡性结肠炎 网络药理学 肿瘤坏死因子 白细胞介素-6 丝裂原活化蛋白激酶3 血管内皮生长因子A |
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| Study on Pharmacological Mechanism of Glycyrrhizae Radix et Rhizoma Used for Treatment of Ulcerative Colitis by Network Pharmacology Approach |
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| Abstract:Objective：To explore the pharmacological mechanism of Glycyrrhizae Radix et Rhizoma on ulcerative colitis by network pharmacology. Methods：The active ingredients and corresponding targets of Glycyrrhizae Radix et Rhizoma were collected by using traditional Chinese medicine systems pharmacology database and analysis platform （TCMSP）.The disease-related genes were retrieved from CTD database.Then the corresponding targets were mapped to the set of disease-related genes to obtain intersection targets.The UniProt database and Cytoscape 3.7.2 software was used to build ″ingredients-targets″ network，protein interaction network and ″ingredients-targets-pathway″ network.Results：A total of 92 active ingredients and 227 potential drug targets of Glycyrrhizae Radix et Rhizoma were obtained according to the screening conditions. There were 41 targets related to ulcerative colitis，such as tumor necrosis factor （TNF），interleukin-6 （IL-6），mitogen-activated protein kinase （MAPK3），vascular endothelial growth factor A （VEGFA） and so on，among the 227 potential drug targets. Glycyrrhizae Radix et Rhizoma exerted its effects on ulcerative colitis mainly by acting on 28 signal pathways，such as IL-17，amoebiasis，inflammatory bowel disease （IBD） and so on. Conclusion：Glycyrrhizae Radix et Rhizoma treats ulcerative colitis through multi-ingredient，multi-target and multi-pathway interaction. This study explores the pharmacological mechanism of Glycyrrhizae Radix et Rhizoma on ulcerative colitis and has a certain reference value for the research and development of new drugs. |
| keywords:Glycyrrhizae Radix et Rhizoma ulcerative colitis network pharmacology tumor necrosis factor interleukin-6 mitogen activated protein kinase 3 vascular endothelial growth factor A |
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