欢迎访问中国现代中药网站

作者中文名	作者英文名	单位中文名	单位英文名	E-Mail
刘自强	LIU Zi-qiang	北京中医药大学，北京102488	Beijing University of Chinese Medicine，Beijing 102488，China
农璐琪	NONG Lu-qi	北京中医药大学，北京102488	Beijing University of Chinese Medicine，Beijing 102488，China
韩梦雨	HAN Meng-yu	北京中医药大学，北京102488	Beijing University of Chinese Medicine，Beijing 102488，China
訾迎新	ZI Ying-xin	北京中医药大学，北京102488	Beijing University of Chinese Medicine，Beijing 102488，China
孟欢	MENG Huan	北京中医药大学，北京102488	Beijing University of Chinese Medicine，Beijing 102488，China
邓宇	DENG Yu	北京中医药大学，北京102488	Beijing University of Chinese Medicine，Beijing 102488，China
邓婷婷	DENG Ting-ting	中日友好医院眼科，北京100029	Department of Ophthalmology，China-Japan Friendship Hospital，Beijing 100029，China
金明	JIN Ming	中日友好医院眼科，北京100029	Department of Ophthalmology，China-Japan Friendship Hospital，Beijing 100029，China	金明，教授，博士生导师，研究方向：中医药防治眼底病；E-mail：jinmingyk@163.com

基金项目:国家自然科学基金项目（81574029）；中医药传承与创新“百千万”人才工程（岐黄工程）岐黄学者项目

中文摘要:目的：探讨丹参治疗视网膜静脉阻塞（RVO）的作用机制。方法：采用中药系统药理学数据库与分析平台（TCMSP）检索丹参的有效化学成分，并收集其对应的作用靶点；使用GeneCards数据库检索与RVO相关的靶点；采用ClusterProfiler R软件绘制交集靶点的韦恩图；采用STRING 11.0数据库构建蛋白质-蛋白质相互作用（PPI）网络，采用Cytoscape 3.7.2 软件构建“药物-活性成分-疾病-靶蛋白”相互作用网络；采用ClusterProfiler R 软件对靶点进行基因本体（GO）和京都基因与基因组百科全书（KEGG）富集分析。结果：得到丹参有效成分41个、药物靶点70个、RVO靶点1705个，最终获得丹参治疗RVO的潜在作用靶点46个，KEGG通路76条。结论：丹参可能通过调控炎症反应、血管生成、凝血过程和细胞凋亡等对RVO发挥治疗作用。

中文关键词:丹参视网膜静脉阻塞网络药理学作用机制

Exploration Mechanism of Salvia miltiorrhiza in Treating Retinal Vein Occlusion Based on Network Pharmacology

Abstract:Objective：To explore the pharmacological mechanism of Salvia miltiorrhiza in the treatment of retinal vein occlusion（RVO）. Methods：The active components of S.miltiorrhiza were screened through Traditional Chinese Medicine Database and Analysis Platform（TCMSP），and the corresponding targets were collected；related targets of RVO were screened through GeneCards database；ClusterProfiler R software was used to draw the Venn diagram of intersection targets；STRING 11.0 database was used for protein-protein interaction（PPI） network；Cytoscape 3.7.2 was used to construct the network of “drug-component-disease-target”. Finally，the gene ontology（GO） and Kyoto encyclopedia of genes and genomes（KEGG） enrichment analysis of key targets were carried out by using the ClusterProfiler R software. Results：There were 41 active components and 79 targets for S.miltiorrhiza. There were 1705 disease-related targets. Finally，there were 46 potential targets for action and 70 KEGG pathways obtained. Conclusion：S.miltiorrhiza might play a role in the treatment of RVO through regulating inflammation response，angiogenesis，coagulation process，apoptosis and so on.

keywords:Salvia miltiorrhiza Bge. retinal vein occlusion network pharmacology mechanism

查看全文查看/发表评论下载PDF阅读器