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作者中文名	作者英文名	单位中文名	单位英文名	E-Mail
冯利梅	FENG Li-mei	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
陈艳琰	CHEN Yan-yan	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China	陈艳琰，副教授，研究方向：中药功效物质基础及配伍关系；E-mail：chenyanyan59@163.com
乐世俊	YUE Shi-jun	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
赵琦	ZHAO Qi	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
黄露	HUANG Lu	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
高欢	GAO Huan	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
毕诗杰	BI Shi-jie	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
栗端威	LI Duan-wei	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China
尚尔鑫	SHANG Er-xin	南京中医药大学江苏省方剂高技术研究重点实验室，江苏南京210023	Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae，Nanjing University of Chinese Medicine，Nanjing 210023，China
唐于平	TANG Yu-ping	陕西中医药大学陕西省中医药管理局中药配伍重点研究室，陕西西安712046	Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility，Shaanxi University of Chinese Medicine，Xi′an 712046，China	唐于平，教授，研究方向：中药配伍效应与功效物质基础；E-mail：yupingtang@sntcm.edu.cn
段金廒	DUAN Jin-ao	南京中医药大学江苏省方剂高技术研究重点实验室，江苏南京210023	Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae，Nanjing University of Chinese Medicine，Nanjing 210023，China

基金项目:陕西省重点研发计划项目（2019SF-300，2019ZDLSF04-05）；陕西高校青年创新团队项目（2020）；陕西省青年科技新星培育计划项目（2021）；陕西中医药大学学科创新团队项目（2019-YL10）

中文摘要:目的：基于中医方剂数据库，通过网络关联分析等数据挖掘方法，探究芍药-甘草药对的配伍应用规律。方法：从中医方剂数据库中检索含芍药、甘草的方剂共7484首，统计方剂中芍药和甘草的用药量、配伍比例、配伍药物、制法用法与方剂功效、科属间的联系，采用Cytoscape 3.7.0、SPSS Modeler等工具对其关系进行挖掘分析并用网络关联图呈现。结果：芍药常用量为31.25 g（1114次）、15.53 g（799次），甘草常用剂量为15.53 g（1043次）、31.25 g（873次）；芍药-甘草常用配伍为1∶1，占总数的37.06%；芍药-甘草常用配伍药为当归、川芎、人参、茯苓、地黄，占总数的16.63%；常用制法用法为水煎、生用内服、酒煎、外用、水酒共煎、膏煎、醋煎；方剂功效以止痛、补虚、解毒、祛风、消肿、明目为主；科属以内科、外科、妇科、儿科、五官科为主。且用药量、配伍比例和制法用法与功效、科属间存在相关关系。结论：研究结果为芍药-甘草药对用于中医临床遣药组方及现代中药研发提供了参考。

中文关键词:芍药甘草药对中医方剂数据库网络关联

Research on Application Rules of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma Based on Traditional Chinese Medicine Formulae Data and Network Correlation Analysis

Abstract:Objective：Based on the database of traditional Chinese medicine （TCM） prescriptions，the compatibility and application rules of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma were explored by data mining methods such as network correlation analysis. Methods：A total of 7484 prescriptions containing Paeoniae Radix and Glycyrrhizae Radix et Rhizoma were retrieved from the database of TCM prescriptions，and the relationship between the dosage，compatibility ratio，compatibility，preparation and usage of Paeoniae Radix-Glycyrrhizae Radix et Rhizoma as well as prescription efficacy and disease attribution was statistically analyzed. Cytoscape 3.7.0，SPSS Modeler and other tools were used to mine and analyze the relationship and present it with network correlation diagram. Results：The results showed that the common dosage of Paeoniae Radix was 31.25 g （1114 times） and 15.53 g （799 times），while that of Glycyrrhizae Radix et Rhizoma was 15.53 g （1043 times） and 31.25 g （873 times）. The common compatibility ratio was 1∶1，accounting for 37.06% of the total. The commonly used compatibility drugs of Paeoniae Radix-Glycyrrhizae Radix et Rhizoma were Angelica sinensis Radix，Chuanxiong Rhizoma，Ginseng Radix et Rhizoma，Poria and Rehmannia Radix，accounting for 16.63% of the total. The commonly used methods were water decocting，raw internal medicine，wine decocting，external uses，water alcohol decocting together，paste decocting，vinegar decocting. The main efficacy of the prescriptions was analgesia，tonic deficiency，detoxification，dispelling wind，detumescence and improving eyesight. Diseases were attributed to internal medicine，surgery，gynaecology，pediatrics，ophthalmology and otorhinolaryngology. In addition，the dosage，compatibility ratio and preparation usage were correlated with efficacy and disease attribution. Conclusion：These findings provide an important scientific basis for the clinical application of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma，and are benifical for the research and development of modern TCM.

keywords:Paeoniae Radix Glycyrrhizae Radix et Rhizoma herb pair TCM formulae database network correlation

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