基于专利信息挖掘与验证的五味子安神用药规律研究
投稿时间:2020-10-21     点此下载全文
引用本文:王月茹,谢伟.基于专利信息挖掘与验证的五味子安神用药规律研究[J].中国现代中药,2021,23(11):1916-1920
DOI:10.13313/j.issn.1673-4890.20201021001
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作者中文名作者英文名单位中文名单位英文名E-Mail
王月茹 WANG Yue-ru 陕西国际商贸学院,陕西 咸阳 712000 Shaanxi Institute of International Trade & Commerce, Xianyang 712000, China  
谢伟* XIE Wei 陕西步长制药有限公司,陕西 咸阳 712000 Shaanxi Buchang Pharmaceutical Co., Ltd., Xianyang 712000, China  
基金项目:陕西省中医药管理局科研项目(SZY-KJCYC-2021-PY-009);陕西省教育厅科研计划项目(19JK0103);陕西省重点研发计划项目(2018SF-275)
中文摘要:目的 对五味子专利文献进行技术信息挖掘,并统计分析具有安神功效的遣药配伍规律,对相关研究结果进行信息验证,以期为五味子的药食效用开发及专利审查提供参考。方法 通过智慧芽专利数据库检索五味子相关有效专利信息,经过人工去噪、筛选确定分析数据样本,利用中医药传承计算平台软件进行聚类分析,形成用药频次、对药、角药及核心遣药配伍组成等规律结果,并参照国家药品标准、上市产品实证及科技文献等对结果进行验证。结果 在五味子安神功效的专利信息分析中发现,对药组合五味子-酸枣仁的频次最高,角药组合五味子-酸枣仁-远志的频次最高,五味子-酸枣仁-丹参-地黄为五味子发挥安神功效拟合的最优组方;在百乐眠胶囊、枣仁安神胶囊等上市中成药的组成配伍信息验证中,五味子组方配伍发挥安神功效拟合新组方是五味子-酸枣仁-丹参-地黄,这一结果与药品标准、上市产品及科技文献等综合信息的系统性验证完全一致。结论 基于有效专利信息拟合的五味子遣药配伍规律能够为该药材的开发利用及专利性审查提供参考,为加强中医药专利信息的挖掘和运用提供路径。
中文关键词:五味子  专利文献  科技文献  药品标准  分析挖掘  信息验证
 
Compatibility Regularity of Schisandrae Chinensis Fructus in Relieving the Uneasiness of Mind Based on Patent Information Mining and Verification
Abstract:Objective To analyze the compatibility regularity of Chinese medicines effective in relieving the uneasiness of mind by information mining and verification of patent literature on Schisandrae Chinensis Fructus to provide effective evidence for the research and development, clinical application, and patent examination of Schisandrae Chinensis Fructus.Methods Patsnap was searched for relevant valid patents of Schisandrae Chinensis Fructus. After manual denoising and screening, the data samples were determined. Traditional Chinese Medicine Inheritance Computing Platform was used for clustering analysis to generate the results of drug frequency, pairwise combination, ternary combination, and core combination of drugs, which were verified according to the national drug standards, demonstration of marketed products, and scientific and technical documents.Results As revealed by the analysis of patent information on tranquilization, the pairwise combination of Schisandrae Chinensis Fructus-Ziziphi Spinosae Semen and the ternary combination of Schisandrae Chinensis Fructus-Ziziphi Spinosae Semen-Polygalae Radix were highest in frequency, and the core combination of Schisandrae Chinensis Fructus-Ziziphi Spinosae Semen-Salviae Miltiorrhizae Radix et Rhizoma-Rehmanniae Radix was the optimal prescription in relieving the uneasiness of mind. The information verification of composition of Chinese patent medicines such as Bailemian Capsules and Zaoren Anshen Capsules demonstrated that Schisandrae Chinensis Fructus-Ziziphi Spinosae Semen-Salviae Miltiorrhizae Radix et Rhizoma-Rehmanniae Radix served as the new drug combination potent in relieving the uneasiness of mind, which was identical to the results of systematic verification of drug standards, marketed products, and scientific literature.Conclusion The compatibility regularity of Schisandrae Chinensis Fructus based on the information of valid patents can provide references for the development and application of Schisandrae Chinensis Fructus and patent examination and inspire the patent data mining and application of traditional Chinese medicine.
keywords:Schisandrae Chinensis Fructus  patent literature  scientific literature  drug standards  analysis and mining  information verification
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