| Box-Behnken设计优化小儿消积止咳制剂提取纯化工艺 |
| 投稿时间：2020-12-02 点此下载全文
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| 引用本文：高艳红,刘金宇,曹玲,崔琳琳,关永霞,张贵民.Box-Behnken设计优化小儿消积止咳制剂提取纯化工艺[J].中国现代中药,2021,23(11):1967-1974 |
| DOI：10.13313/j.issn.1673-4890.20201202001 |
| 摘要点击次数: 291 |
| 全文下载次数: 140 |
| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 高艳红 |
GAO Yan-hong |
鲁南制药集团股份有限公司 中药制药共性技术国家重点实验室，山东 临沂 276006
鲁南厚普制药有限公司，山东 临沂 276006 |
State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China
Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006, China |
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| 刘金宇 |
LIU Jin-yu |
鲁南厚普制药有限公司，山东 临沂 276006 |
Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006, China |
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| 曹玲 |
CAO Ling |
鲁南制药集团股份有限公司 中药制药共性技术国家重点实验室，山东 临沂 276006
鲁南厚普制药有限公司，山东 临沂 276006 |
State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China
Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006, China |
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| 崔琳琳 |
CUI Lin-lin |
鲁南制药集团股份有限公司 中药制药共性技术国家重点实验室，山东 临沂 276006
鲁南厚普制药有限公司，山东 临沂 276006 |
State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China
Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006, China |
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| 关永霞* |
GUAN Yong-xia |
鲁南制药集团股份有限公司 中药制药共性技术国家重点实验室，山东 临沂 276006
鲁南厚普制药有限公司，山东 临沂 276006 |
State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China
Lunan Houpu Pharmaceutical Co., Ltd., Linyi 276006, China |
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| 张贵民 |
ZHANG Gui-min |
鲁南制药集团股份有限公司 中药制药共性技术国家重点实验室，山东 临沂 276006 |
State Key Laboratory of Generic Manufacture Technology of Traditional Chinese Medicine of Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China |
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| 基金项目:国家重点研发计划中医药现代化研究重点专项（2019YFC1711205）；山东省级产业集群项目（临兰财企字〔2018〕43号） |
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| 中文摘要:目的 优选小儿消积止咳制剂的提取纯化工艺。方法 以辛弗林转移率、柚皮苷转移率和干物质得率为综合评价指标，通过单因素试验及响应曲面法分别考察料液比、提取数、提取时间对小儿消积止咳制剂水提工艺的影响及浸膏相对密度、醇沉醇度、醇沉时间对小儿消积止咳制剂醇沉工艺的影响。结果 最佳提取纯化工艺为料液比1∶8，提取数3次，提取时间100 min，醇沉浸膏相对密度1.20，醇沉醇度60%，醇沉时间20 h。结论 采用Box-Behnken设计优选的小儿消积止咳制剂提取纯化工艺科学、合理、可行。 |
| 中文关键词:Box-Behnken设计 小儿消积止咳制剂 提取纯化工艺 |
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| Optimization of Purification Process of Xiaoer Xiaoji Zhike Preparation by Box-Behnken Design |
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| Abstract:Objective To optimize the extraction and purification process of Xiaoer Xiaoji Zhike Preparation and lay a basis for the future research.Methods With the transfer rate of synephrine, transfer rate of naringin, and dry matter yield as evaluation indexes, the influence of material-to-liquid ratio, extraction times, and extraction duration in the water extraction process and the effect of the relative density of the extract, volume fraction of ethanol for precipitation, and precipitation duration in the ethanol precipitation process of Xiaoer Xiaoji Zhike Preparation were investigated by single factor test and response surface methodology, respectively.Results The optimal extraction and purification parameters are as follows: material-to-liquid ratio of 1∶8, extraction for 100 min with a total of 3 times, extract density of 1.20, 60% ethanol, and precipitation for 20 h.Conclusion The purification process of the Xiaoer Xiaoji Zhike Preparation optimized by Box-Behnken design is scientific, reasonable, and feasible. |
| keywords:Box-Behnken design Xiaoer Xiaoji Zhike Preparation extraction and purification process |
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