| 响应曲面法优化败毒散提取工艺 |
| 投稿时间：2020-11-12 点此下载全文
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| 引用本文：徐坤勇,郭建忠,颜娟,韵国萍.响应曲面法优化败毒散提取工艺[J].中国现代中药,2021,23(11):1975-1981 |
| DOI：10.13313/j.issn.1673-4890.20201112003 |
| 摘要点击次数: 331 |
| 全文下载次数: 130 |
| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 徐坤勇 |
XU Kun-yong |
张家口市第一医院 药学部，河北 张家口 075000 |
Department of Pharmacy, First Hospital of Zhangjiakou City, Zhangjiakou 075000, China |
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| 郭建忠 |
GUO Jian-zhong |
张家口市第一医院 药学部，河北 张家口 075000 |
Department of Pharmacy, First Hospital of Zhangjiakou City, Zhangjiakou 075000, China |
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| 颜娟 |
YAN Juan |
河北北方学院 附属第一医院 药学部，河北 张家口 075000 |
Department of Pharmacy, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China |
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| 韵国萍* |
YUN Guo-ping |
张家口市第一医院 药学部，河北 张家口 075000 |
Department of Pharmacy, First Hospital of Zhangjiakou City, Zhangjiakou 075000, China |
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| 基金项目:河北省中医药管理局科研计划项目（2019536） |
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| 中文摘要:目的 优化败毒散的提取工艺。方法 以收膏率和柚皮苷、新橙皮苷含量的综合得分为考察指标，在单因素试验的基础上，采用响应曲面法考察液料比、提取时间及提取数对败毒散提取工艺的影响。结果 最佳提取工艺条件为液料比14∶1，水煎煮法提取170 min，提取2次，在该条件下，综合得分为87.67%。结论 该优化工艺方法准确可靠。 |
| 中文关键词:败毒散 柚皮苷 新橙皮苷 提取工艺 响应曲面 |
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| Optimization of Extraction of Baidu Powder by Response Surface Methodology |
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| Abstract:Objective To optimize the extraction of Baidu Powder.Methods The response surface methodology (RSM) was used to investigate the effects of liquid-to-solid ratio, extraction time, and extraction times on the extraction of Baidu Powder based on a single factor test with the comprehensive scores of extract yield and the content of naringin and neohesperidin as indicators.Results The optimal extraction was achieved by water decocting twice, 170 min each time at a liquid-to-solid ratio of 14∶1. Under such conditions, the comprehensive score was 87.67%.Conclusion The extraction processing after optimization was accurate and reliable. |
| keywords:Baidu Powder naringin neohesperidin extraction processing RSM |
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