| 八角枫的化学成分研究 |
| 投稿时间：2021-09-02 点此下载全文
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| 引用本文：岳跃栋,付小彬,孙国栋.八角枫的化学成分研究[J].中国现代中药,2022,24(5):805-811 |
| DOI：10.13313/j.issn.1673-4890.20210902003 |
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| 基金项目:医学科研发展基金项目（HS202008） |
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| 中文摘要:目的 研究八角枫科八角枫属植物八角枫Alangium chinense（Lour.）Harms的化学成分。方法 采用各种柱色谱及半制备液相色谱分离纯化，经波谱数据鉴定化合物结构。结果 从八角枫根的正丁醇萃取物中分离得到21个化合物，其结构分别鉴定为 (+)-异落叶松树脂醇-3α-O-β-D-吡喃葡萄糖苷（1）、(+)-南烛树脂醇-3α-O-β-D-吡喃葡萄糖苷（2）、(7S,8R)-川素馨木脂苷（3）、枇杷苷（4）、(6R,9R)-大柱香波龙烷-4-烯-9-醇-3-酮-O-β-D-(6′-O-β-D-呋喃芹糖基) 吡喃葡萄糖苷（5）、马钱酸（6）、(1S,4S)-7-羟基去氢白菖烯（7）、(1R,4S)-7-羟基去氢白菖烯（8）、八角枫碱（9）、尿嘧啶（10）、尿苷（11）、胸苷（12）、5-羟基-2-羟甲基吡啶（13）、2,6-去氧果糖嗪（14）、3,4′-O-β-D-二甲基逆没食子酸（15）、3′-O-β-D-甲基-3,4-亚甲二氧基鞣花酸-4′-O-β-D-吡喃葡萄糖苷（16）、水杨醇（17）、香草醛（18）、没食子酸（19）、没食子酸甲酯（20）、没食子酸乙酯（21）。结论 化合物1~6为首次在八角枫属中分离得到。 |
| 中文关键词:八角枫 八角枫属 化学成分 木脂素 生物碱 |
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| Chemical Constituents of Alangium chinense |
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| Abstract:Objective To study the constituents of Alangium chinense (Lour.) Harms.Methods The compounds were isolated and purified by column chromatography and semi-preparative high performance liquid chromatography (HPLC), and their chemical structures were identified by spectral techniques.Results A total of 21 compounds were isolated from the roots of A. chinense and identified as (+)-isolariciresinol 3α-O-β-D-glucopyranoside (1), (+)-lyoniresinol 3α-O-β-D-glucopyranoside (2), (7S,8R)-urolignoside (3), (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one-9-O-β-D-(6′-O-β-D-apiofuranosyl)glucopyranoside (4), (6R,9R)-megastigman-4-en-9-ol-3-one-O-β-D-(6′-O-β-D-apiofuranosyl)glucopyranoside (5), loganin acid (6), (1S, 4S)-7-hydroxycalamenene (7), (1R,4S)-7-hydroxycalamenene (8), anabasine (9), uracil (10), uridine (11), thymidine (12), 2-hydroxymethyl-5-hydroxypyridine (13), 2,6-deoxyfructosazine (14), 3,4′-O-β-D-dimethylellagic acid (15), 3′-O-β-D-methyl-3,4-methylenedioxyellagic acid 4′-O-β-D-glucopyranoside (16), salicylic alcohol (17), vanillin (18), gallic acid (19), gallicin (20), ethyl gallate (21).Conclusion Compounds 1-6 were isolated from Alangium for the first time. |
| keywords:Alangium chinense (Lour.) Harms Alangium constituents lignans alkaloids |
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