| 防风化学成分 药理作用研究进展及质量标志物预测分析 |
| 投稿时间：2021-11-15 点此下载全文
|
| 引用本文：常潞,荆文光,程显隆,魏锋,马双成.防风化学成分 药理作用研究进展及质量标志物预测分析[J].中国现代中药,2022,24(10):2026-2039 |
| DOI：10.13313/j.issn.1673-4890.20211115003 |
| 摘要点击次数: 333 |
| 全文下载次数: 87 |
| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 常潞 |
CHANG Lu |
中国药科大学 中药学院，江苏 南京 211198
中国食品药品检定研究院，北京 100050 |
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
National Institutes for Food and Drug Control, Beijing 100050, China |
|
| 荆文光 |
JING Wen-guang |
中国食品药品检定研究院，北京 100050 |
National Institutes for Food and Drug Control, Beijing 100050, China |
|
| 程显隆 |
CHENG Xian-long |
中国食品药品检定研究院，北京 100050 |
National Institutes for Food and Drug Control, Beijing 100050, China |
|
| 魏锋* |
WEI Feng |
中国食品药品检定研究院，北京 100050 |
National Institutes for Food and Drug Control, Beijing 100050, China |
|
| 马双成 |
MA Shuang-cheng |
中国食品药品检定研究院，北京 100050 |
National Institutes for Food and Drug Control, Beijing 100050, China |
|
|
| 基金项目:国家重点研发计划项目（2019YFC1711505）；中国食品药品检定研究院中药民族药检定所学科建设项目（1020050090116） |
|
| 中文摘要:防风是中国的传统中药材，广泛分布于东北、华北等地，其化学成分主要包括挥发油类、色原酮类和香豆素类，具有解表祛风、胜湿、止痛止痉的功效。现代研究认为，其与传统功效相关的药理作用主要体现在解热、镇痛、抗炎方面，主要活性成分为色原酮类化合物。基于对防风物质基础及药理作用研究进展的总结，从化学成分特有性、可测性，药效药性关联性，道地性和生产规范性等角度对防风潜在的质量标志物（Q-marker）进行预测，初步确定5-O-甲基维斯阿米醇苷、升麻素、亥茅酚苷为潜在的可区分防风道地性的Q-marker，5-O-甲基维斯阿米醇苷、升麻素、升麻素苷、亥茅酚苷、5-O-甲基维斯阿米醇为潜在的可区分防风药效的Q-marker，可为全面控制防风质量和提升防风质量标准提供参考。 |
| 中文关键词:防风 质量标志物 化学成分 药理作用 色原酮 香豆素 |
| |
| Research Progress on Chemical Constituents and Pharmacological Effects of Saposhnikoviae Radix and Predictive Analysis on Its Q-Marker |
|
|
| Abstract:Saposhnikoviae Radix is a Chinese medicinal material widely distributed in Northeast China, North China and other regions. Its chemical components mainly include volatile oils, chromones and coumarins, with the functions of releasing exterior, dispelling wind, eliminating dampness, and stopping pain and convulsions. Modern research believes that its pharmacological effects related to traditional effects are mainly reflected in antipyretic, analgesic, and anti-inflammatory aspects, and the main related active components are chromone compounds. Based on the summary of the material basis and pharmacological effects of Saposhnikoviae Radix, this paper predicted its potential quality marker (Q-marker) from the perspectives of chemical component specificity, measurability, relevance of pharmacodynamics and drug property, geo-authentic producing area and production standard. According to prediction, 4?-O-β-D-5-O-methylvisamidol, cimifugin, sec-O-glucosylhamaudol were preliminarily determined as the potential Q-markers that could distinguish the geo-authenticity of Saposhnikoviae Radix. 4?-O-β-D-5-O-methylvisamidol, cimifugin, prim-O-glucosylcimifugin, sec-O-glucosylhamaudol, and 5-O-methylvisamiol were the potential Q-marker that could distinguish the efficacy of Saposhnikoviae Radix. This paper provided reference for comprehensive control of the quality of Saposhnikoviae Radix and improvement of its quality standards. |
| keywords:Saposhnikoviae Radix Q-marker chemical components pharmacological effects chromone coumarin |
|
查看全文
查看/发表评论 下载PDF阅读器 |
|
|
|
