Box-Behnken设计优化小儿消积止咳制剂提取纯化工艺
投稿时间:2020-12-02  修订日期:2021-01-07   点此下载全文
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作者中文名作者英文名单位中文名单位英文名E-Mail
高艳红 gaoyanhong 鲁南制药集团股份有限公司 lunanzhiyao yanhonggao2012@163.com 
刘金宇 LIU Jinyu 厚普制药有限公司 Lunan Houpu Pharmaceutical Co., Ltd. lngmp@126.com 
曹玲 CAO Ling 鲁南制药集团股份有限公司 Lunan Pharmaceutical Group Co., Ltd. 1412647633@qq.com 
崔琳琳 CUI Lin-lin 鲁南制药集团股份有限公司 Lunan Pharmaceutical Group Co., Ltd. 975966794@qq.com 
关永霞* GUAN Yong-xia 鲁南制药集团股份有限公司 Lunan Pharmaceutical Group Co., Ltd. 13581069215@163.com 
张贵民 ZHANG Gui-min 鲁南制药集团股份有限公司 Lunan Pharmaceutical Group Co., Ltd. lunanzhangguimin@163.com 
基金项目:国家重点研发计划中医药现代化研究重点专项(2019YFC1711205);山东省级产业集群项目项目 (临兰财企字[2018]43号)
中文摘要:目的:优化小儿消积止咳制剂的提取纯化工艺。方法:以辛弗林转移率、柚皮苷转移率和干物质得率综合评分为考察指标,在单因素实验的基础上,分别考察影响小儿消积止咳制剂的水提工艺因素(料液比、提取次数、提取时间)以及醇沉因素(浸膏相对密度、醇沉醇度、醇沉时间),通过Box-Behnken设计优选最佳提取纯化工艺。结果:最佳提取纯化工艺为:料液比1:8,提取次数为3次,提取时间为100 min,醇沉浸膏相对密度1.20,醇沉醇度60%,醇沉时间20 h。结论:采用Box-Behnken设计优选的小儿消积止咳制剂提取纯化工艺科学、合理、可行。
中文关键词:Box-Behnken设计  小儿消积止咳制剂  提取纯化工艺
 
Optimization of The Purification Process of Xiaoerxiaojizhike Preparation by Box-Behnken Design
Abstract:Objective: Optimize and determine the best extraction and purification process of Xiaoerxiaojizhike Preparation. Method: Take the synthetic scores of synephrine t-ransfer rate, naringin transfer rate and dry matter yield as the inspection index, On the basis of single-factor experiments, the water extraction process factors (material-liquid ratio 、Number of extractions、extraction time )and alcohol pre-cipitation factors (relative density of extract、ethanol concentration、alcohol pre-cipitation time )that affect the purification process of Xiaoerxiaojizhike preparat-ions were investigated separately. Results: The optimum extraction and purification process was as follows: the ratio of solid to liquid was 1:8, the extraction times were 3, the extraction time was 100 min, the relative density of alcohol precipitation extract was 1.20, the alcohol precipitation degree was 60%, and the alcohol precipitation time was 20 h. Conclusion: The purification process of the Xiaoerxiaojizhike preparation designed and optimized by Box-Behnken is scientific, reasonable and feasible.
keywords:Box-Behnken design  xiaoerxiaojizhike preparation  extraction and purification tech-nology
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