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三种何首乌单体成分对大鼠肝损伤作用的研究

投稿时间：2018-12-21 点此下载全文

引用本文：颜玉静,文海若,淡墨,吕建军,王超,苗玉发,黄芝瑛,汪祺.三种何首乌单体成分对大鼠肝损伤作用的研究[J].中国现代中药,2019,21(8):1054-1061

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作者中文名	作者英文名	单位中文名	单位英文名	E-Mail
颜玉静	YAN Yu-jing	中山大学药学院，广东广州510006	School of Phamaceutical Sciences，Sun Yat-sen University，Guangzhou 510006，China
文海若	WEN Hai-ruo	中国食品药品检定研究院国家药物安全评价监测中心/药物非临床安全评价研究北京市重点实验室，北京100176	National Center for Safety Evaluation of Drugs，National Institutes for Food and Drug Control，Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs，Beijing 100176，China
淡墨	DAN Mo	中国食品药品检定研究院国家药物安全评价监测中心/药物非临床安全评价研究北京市重点实验室，北京100176	National Center for Safety Evaluation of Drugs，National Institutes for Food and Drug Control，Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs，Beijing 100176，China
吕建军	LYU Jian-jun	中国食品药品检定研究院国家药物安全评价监测中心/药物非临床安全评价研究北京市重点实验室，北京100176	National Center for Safety Evaluation of Drugs，National Institutes for Food and Drug Control，Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs，Beijing 100176，China
王超	WANG Chao	中国食品药品检定研究院国家药物安全评价监测中心/药物非临床安全评价研究北京市重点实验室，北京100176	National Center for Safety Evaluation of Drugs，National Institutes for Food and Drug Control，Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs，Beijing 100176，China
苗玉发	MIAO Yu-fa	中国食品药品检定研究院国家药物安全评价监测中心/药物非临床安全评价研究北京市重点实验室，北京100176	National Center for Safety Evaluation of Drugs，National Institutes for Food and Drug Control，Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs，Beijing 100176，China
黄芝瑛	HUANG Zhi-ying	中山大学药学院，广东广州510006	School of Phamaceutical Sciences，Sun Yat-sen University，Guangzhou 510006，China	黄芝瑛，教授，研究方向：药物安全性评价；Tel：（020）39943025，E-mail：hzhiying@mail.sysu.edu.cn
汪祺	WANG Qi	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China	汪祺，副研究员，研究方向：药理毒理；Tel：（010）67395282，E-mail：sansan8251@sina.com

基金项目:国家自然科学基金（81503347）；国家十三五“重大新药创制”专项（2018ZX09201017）

中文摘要:目的：探究三种何首乌单体对SD大鼠潜在肝脏毒性。方法：雄性SD大鼠随机分为对照组（0.5%羧甲基纤维素钠）及大黄素-8-O-β-D-葡萄糖苷28、280、1120 mg·kg-1剂量组，单蒽酮6.5、65、650 mg·kg-1剂量组，大黄素甲醚6.5、65、650 mg·kg-1剂量组，连续14 d经口灌胃给药，观察动物临床症状，分析体质量、肝脏质量、血清生化指标及病理学指标变化，并检测IL-6、IL-10、TNF-α和IFN-γ的表达水平。结果：连续14 d给予SD大鼠3种何首乌单体对动物无明显整体毒性和肝脏毒性作用，但与对照组相比，三种单体给药组IL-10水平均降低（P＜0.05），大黄素甲醚给药组IL-6和TNF-α水平升高（P＜0.05），单蒽酮给药组IFN-γ水平降低（P＜0.05）。结论：本研究可见大黄素甲醚存在潜在肝损伤作用。

中文关键词:何首乌大黄素-8-O-β-D-葡萄糖苷单蒽酮大黄素甲醚肝损伤 SD大鼠 IL-6 IL-10 TNF-α IFN-γ

Effects of Three Polygonum multiflorum Monomers on Liver Injury in Rats

Abstract:Objective：To investigate the potential hepatotoxicity effects of three Polygonum multiflorum monomers in SD rats.Methods：Male SD rats were randomly divided into control（0.5% sodium carboxymethyl cellulose），28，280，1120 mg·kg-1 of emodin-8-O-β-D-glucoside groups，6.5，65，650 mg·kg-1 of anthrone groups and 6.5，65，650 mg·kg-1 of physcion groups，and administrated through oral gavage for consecutive 14 days.Clinical symptoms，body weight，liver weight，serum biochemical examinations data and histopathological examination results were analyzed，and the levels of IL-6，IL-10，TNF-α and IFN-γ were detected.Results：No definite overall toxicity associated with three monomers was observed in SD rats repeated dosed for consecutively 14 days.However，compared with the control group，the levels of IL-10 were elevated in three medicated groups（P＜0.05），the levels of IL-6 and IFN-γ were elevated in physcion groups（P＜0.05）and the levels of IFN-γ were decreased in anthrone groups（P＜0.05）.Conclusion：This study demonstrated the potential liver injury caused by physcion.

keywords:Polygonum multiflorum emodin-8-O-β-D-glucoside anthrone physcion liver injury SD rat IL-6 IL-10 TNF-α IFN-γ

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