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细柱五加的化学成分及药理活性研究概述

投稿时间：2019-07-25 点此下载全文

引用本文：杨建波,蔡伟,李明华,李宁新,马双成,程显隆,魏锋.细柱五加的化学成分及药理活性研究概述[J].中国现代中药,2020,22(4):652-662

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作者中文名	作者英文名	单位中文名	单位英文名	E-Mail
杨建波	YANG Jian-bo	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China
蔡伟	CAI Wei	湖南医药学院药学院，湖南怀化418000	School of Pharmaceutical Sciences，Hunan University of Medicine，Huaihua 418000，China
李明华	LI Ming-hua	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China
李宁新	LI Ning-xin	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China
马双成	MA Shuang-cheng	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China	马双成，研究员，研究方向：中药民族药质量标准及安全性评价研究；Tel：（010）67095993，E-mail：masc@nifdc.org.cn
程显隆	CHENG Xian-long	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China
魏锋	WEI Feng	中国食品药品检定研究院中药民族药检定所，北京100050	Institute for Control of Chinese Traditional Medicine and Ethnic Medicine，National Institutes for Food and Drug Control，Beijing 100050，China	魏锋，研究员，研究方向：中药质量控制研究；Tel：（010） 67095432，E-mail：weifeng@nifdc.org.cn

基金项目:国家自然科学基金资助项目（81773874，81703665）；国家重大新药创制专项（2018ZX09735006）

中文摘要:细柱五加Acanthopanax gracilistylus W.W.Smith为五加科五加属植物，在我国分布广泛，其干燥根皮为中国传统中药五加皮，习称“南五加皮”，主要含有挥发油、萜类和有机酸等成分，具有抗炎、抗疲劳、抗衰老和降血糖等生物活性。本研究分析了1984—2019年国内外细柱五加的研究概况，并从化学成分和药理活性2个方面对其进行了详细地阐释，为将来更好地开发利用细柱五加提供参考。

中文关键词:细柱五加化学成分药理活性

Progress in Chemical and Pharmacological Research of Acanthopanax gracilistylus

Abstract:Acanthopanax gracilistylus is widely distributed in China and belongs to genus Acanthopanax （Araliaceae）.Its dried root bark，known as wujiapi，is listed officially in the Chinese Pharmacopoeia as Acanthopanacis Cortex.It has been used as a traditional Chinese medicine，mainly contains volatile oil，terpenoids，phenolic acid，etc.As a traditional Chinese medicine，A.gracilistylus shows active effects，such as anti-inflammatory，antifatigue，anti-ageing and anti-diabetic effects.This paper mainly collects and analyses the research progress of A.gracilistylus in recent 35 years at home and abroad.The chemical constituents and pharmacological effects of A.gracilistylus are summarized in this review.The results will provide references for exploiting and utilizing A.gracilistylus in the future.

keywords:Acanthopanax gracilistylus chemical constituents pharmacological activity

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