银线草化学成分研究 |
投稿时间:2020-04-23 点此下载全文
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引用本文:王传琦,金新宇,韩悦,刘心雨,柳莹,庄鹏宇.银线草化学成分研究[J].中国现代中药,2021,23(3):437-440 |
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基金项目:河北省自然科学基金项目(H2015209094,H2014209241) |
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中文摘要:目的:对金粟兰属植物银线草Chloranthus japonicus Sieb.全草的化学成分进行研究,以探究其药理活性物质基础。方法:采用硅胶、凝胶Sephadex LH-20、半自动制备液相等色谱方法对银线草的乙酸乙酯部位进行分离纯化,通过1D-NMR、紫外(UV)光谱、质谱(MS)技术对化合物的结构进行鉴定。结果:从银线草75%乙醇提取物的乙酸乙酯部位共分离得到9个化合物,分别鉴定为金合欢素(1)、千层纸素A(2)、7E-3,4-二氧甲基苯并[2-苯基-胸苷](3)、落叶松脂素(4)、9α-羟基紫菀内酯(5)、银线草醇B(6)、金粟兰素C(7)、白术内酯Ⅲ(8)、白术内酯Ⅱ(9)。结论:化合物14为首次在金粟兰属中分离得到。 |
中文关键词:银线草 金粟兰属 金合欢素 千层纸素A 7E-3,4-二氧甲基苯并[2-苯基-胸苷] 落叶松脂素 |
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Study on Chemical Constituents of Chloranthus japonicus |
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Abstract:Objective:To study chemical constituents of the whole plant of Chloranthus japonicus Sieb.and explore the basis of pharmacological substances. Methods:The compounds were isolated and purified by repeated silica gel,gel Sephadex LH-20 and semi-automatic preparative liquid chromatography form EtOAc extraction of C. japonicus. The structure of the compound was identified by 1D-NMR,UV and MS. Results:Nine compounds were isolated,which were identified as acacetin (1),6-methoxybaicalein (2),7E-3,4-dioxymethylenzimtsaure-[2-phenyle-thylamid](3),lariciresinol (4),9α-hydroxyasterolide (5),shizukaol B (6),spicachlorantin C(7),atractylenolide Ⅲ(8),atractylenolide Ⅱ(9). Conclusion:Compounds 14 were isolated from japonicus for the first time. |
keywords:Chloranthus japonicus Sieb. Chloranthus acacetin 6-methoxybaicalein 7E-3,4-dioxymethylenzimtsaure-[2-phenyle-thylamid] lariciresinol |
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