| 经典名方升陷汤的研究进展及质量标志物的预测分析 |
| 投稿时间：2023-09-06 点此下载全文
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| 引用本文：周浩明,乐世俊,刘文娟,崔东晓,付瑞嘉,唐于平.经典名方升陷汤的研究进展及质量标志物的预测分析[J].中国现代中药,2024,26(3):550-565 |
| DOI：10.13313/j.issn.1673-4890.20230906005 |
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| 作者中文名 | 作者英文名 | 单位中文名 | 单位英文名 | E-Mail |
| 周浩明 |
ZHOU Hao-ming |
陕西中医药大学 陕西省中医药管理局中药配伍重点实验室，陕西 西安 712046 |
Key Laboratory of Shannxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shannxi University of Chinese Medicine, Xi'an 712046, China |
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| 乐世俊* |
YUE Shi-jun |
陕西中医药大学 陕西省中医药管理局中药配伍重点实验室，陕西 西安 712046
河北中医药大学 河北省中药资源利用与质量评价国际联合研究中心，河北 石家庄 050200 |
Key Laboratory of Shannxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shannxi University of Chinese Medicine, Xi'an 712046, China
Hebei International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China |
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| 刘文娟 |
LIU Wen-juan |
陕西中医药大学 陕西省中医药管理局中药配伍重点实验室，陕西 西安 712046 |
Key Laboratory of Shannxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shannxi University of Chinese Medicine, Xi'an 712046, China |
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| 崔东晓 |
CUI Dong-xiao |
陕西中医药大学 陕西省中医药管理局中药配伍重点实验室，陕西 西安 712046 |
Key Laboratory of Shannxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shannxi University of Chinese Medicine, Xi'an 712046, China |
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| 付瑞嘉 |
FU Rui-jia |
陕西中医药大学 陕西省中医药管理局中药配伍重点实验室，陕西 西安 712046 |
Key Laboratory of Shannxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shannxi University of Chinese Medicine, Xi'an 712046, China |
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| 唐于平* |
TANG Yu-ping |
陕西中医药大学 陕西省中医药管理局中药配伍重点实验室，陕西 西安 712046 |
Key Laboratory of Shannxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shannxi University of Chinese Medicine, Xi'an 712046, China |
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| 基金项目:陕西省中医药管理局基于大数据的中医药防治新冠真实世界研究与应用（ZYJXG-L23001） |
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| 中文摘要:经典名方升陷汤由黄芪、知母、柴胡、升麻和桔梗组成，主治大气下陷证，现代临床主要用于治疗循环和呼吸系统的疾病。对近年来升陷汤化学成分、药理作用和临床应用的研究进展进行整理归纳和分析，并从质量传递与溯源、成分可测性、成分有效性、成分特有性及复方配伍环境5个方面对升陷汤质量标志物（Q-marker）进行预测，分析发现黄芪甲苷、毛蕊异黄酮苷、毛蕊异黄酮、芒柄花苷、芒柄花素、柴胡皂苷A、柴胡皂苷D、芒果苷、知母皂苷B-Ⅱ、阿魏酸、异阿魏酸和桔梗皂苷D可作为升陷汤的Q-marker，为经典名方升陷汤质量控制体系和全过程质量溯源体系建立提供科学依据。 |
| 中文关键词:升陷汤 质量标志物 化学成分 药理作用 临床应用 |
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| Research Progress on Classical Prescription Shengxian Decoction and Predictive Analysis of Its Q-markers |
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| Abstract:Classical prescription Shengxian Decoction, composed of Radix Astragali, Rhizoma Anemarrhenae, Radix Bupleuri, Rhizoma Cimicifugae and Radix Platycodonis, is mainly used to treat the sinking of pectoral qi. Clinically, the prescription is widely used for the treatment of circulatory and respiratory system diseases. In this paper, the research progress on the chemical component, pharmacological action and clinical application of Shengxian Decoction in recent years was summarized and analyzed, and the quality markers (Q-markers) were predicted from five aspects: quality transfer and traceability, component measurability, component effectiveness, component specificity and compound compatibility. The result showed that astragaloside Ⅳ, calycosin-7-O-β-D-glucoside, caylcosin, ononin, formononetin, saikosaponin A, saikosaponin D, mangiferin, timosaponin B-Ⅱ, ferulic acid, isoferulic acid and platycodon D could be used as Q-markers for Shengxian Decoction, which provided scientific basis for the establishment of the quality control system and the whole-process quality traceability system of the prescription. |
| keywords:Shengxian Decoction quality marker chemical component pharmacological action clinical application |
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