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作者中文名	作者英文名	单位中文名	单位英文名	E-Mail
雷蕾	Lei Lei	中国中医科学院中医药信息研究所，北京100700	Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700,China
赵凤丹	Zhao Fengdan	中国中医科学院中医药信息研究所，北京100700	Beijing University of Chinese Medicine，Beijing 100700，China
邢雁辉	Xing Yanhui	中国中医科学院中医药信息研究所，北京100700	Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700,China
杨策	Yang Ce	中国中医科学院中医药信息研究所，北京100700	Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700,China
张竹绿	Zhang Zhulv	中国中医科学院中医药信息研究所，北京100700	Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700,China
亢力	Kangli	中国中医科学院中医药信息研究所，北京100700	Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700,China	亢力，助理研究员, 研究方向：中医药信息学；E-mail：kangli@mail.cintcm.ac.cn
尹仁芳	Yin Renfang	中国中医科学院中医药信息研究所，北京100700	Institute of Information on Traditional Chinese Medicine，China Academy of Chinese Medical Sciences，Beijing 100700,China

基金项目:中国中医科学院自主选题项目（编号：ZZ090322）；中国中医科学院自主课选题项目（编号：ZZ090304）

中文摘要:目的：探讨国内降血糖保健食品的主要成分及其共现关系，为保健食品开发提供参考。方法：本文基于567个国内改善睡眠类保健食品的说明书，使用数据统计和关联规则挖掘算法，分析了保健食品生产厂家、生产地域、保健食品的主要成分，以及成分之间的高频组合、强关联关系，并使用复杂网络图形化展示了中药-化学成分-靶点的关系。结果：在567个保健食品中，涉及的生产厂家492个，厂家分布在30个省市，以北京遥遥领先。北京唐安营养保健食品有限公司和天津阿尔发保健食品有限公司的产品最多，涉及成分248个，苦瓜及提取物最多。吡啶甲酸铬和苦瓜及提取物共现频次最高（支持度最高），苦瓜及提取物、蜂胶及提取物和吡啶甲酸铬关系最为紧密（置信度最高）。通过对高频药对包含的化学成分和对应的靶点分析，发现出现较多的化学成分槲皮素（quercetin）和靶点肿瘤坏死因子（Tumor necrosis factor）与糖尿病密切相关。结论：本文通过对保健食品的厂家和主要成分进行了分析，并得出一些有意义的结果，可以为保健食品开发提供参考。

中文关键词:糖尿病保健食品关联规则复杂网络

Analysis of Domestic Status forHypoglycemic Health Products

Abstract:Objective：To provide a reference for the development of health care products，we investigated the status of the domestic hypoglycemic health care products.Methods：This paper based on 567 domestic health care products which help reduce blood sugar，we used data statistics and association rule mining algorithm，analyzed the health care products manufacturers，production region，the main ingredients of health care products，and the high frequency combination and strong correlation between ingredients，and finally used complex network to demonstrate the relationship of traditional Chinese medicine，chemical composition and target.Results：There were 492 manufacturer producing 567 products and Beijing Tangan nutritional health products company and Tianjin Aerfa Health Products company had the most products.The manufacturers located in 30 provinces and cities，and Beijing stand on the top.The 567 health care products contained 248 components，in which balsam pear （including its extract） appeared the most frequently.At the same time，it was found that the common frequency of chromium picolinate and balsam pear （including its extract） was the highest （the highest degree of support），while the relationship between balsam pear （including its extract），propolis （including its extract） and chromium picolinate was the closest （the highest degree of confidence）.Through the analysis of high frequency components and the corresponding target，it was found that component quercetin and targets tumor necrosis factor were related to diabetes mellitus.Conclusion：This paper analyzes the manufacturers and the main components of health care products，and draws some meaningful results，it can provide reference for the development of health care products.

keywords:Diabetes,health products,association rules,complex networks

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