颠倒散治疗痤疮的药效物质基础、作用机制研究进展及质量标志物的预测分析
投稿时间:2022-12-22     点此下载全文
引用本文:高芳芳,单晓晓,张瑞雪,张彩云,徐宁雯,张玟,郭蕊含,葛坤坤.颠倒散治疗痤疮的药效物质基础、作用机制研究进展及质量标志物的预测分析[J].中国现代中药,2023,25(4):930-942
DOI:10.13313/j.issn.1673-4890.20220905001
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作者中文名作者英文名单位中文名单位英文名E-Mail
高芳芳 GAO Fang-fang 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
单晓晓 SHAN Xiao-xiao 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
张瑞雪 ZHANG Rui-xue 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
张彩云* ZHANG Cai-yun 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
徐宁雯 XU Ning-wen 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
张玟 ZHANG Wen 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
郭蕊含 GUO Rui-han 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
葛坤坤 GE Kun-kun 安徽中医药大学 药学院 药物制剂技术与应用安徽省重点实验室,安徽 合肥 230012
安徽省教育厅现代药物制剂工程技术研究中心,安徽 合肥 230012
安徽省道地中药材品质提升创新协同中心,安徽 合肥 230012
安徽省中医药科学院 药物制剂研究所,安徽 合肥 230012
中药复方安徽省重点实验室,安徽 合肥 230012
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei 230012, China
Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center, Hefei 230012, China
Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei 230012, China
Anhui Key Laboratory of Compound Chinese Materia Medica, Hefei 230012, China
 
基金项目:安徽省科技重大专项(202203a07020031);安徽省教育厅基金项目(KJ2021ZD0065);安徽省教育厅自然科学基金重点项目(KJ2019A0432);安徽中医药大学大学生创新创业训练计划项目(202110369019)
中文摘要:颠倒散出自清代《医宗金鉴》,主治酒渣鼻、肺风粉刺,是现代临床上治疗黑头粉刺、脂溢性皮炎和丘疹性脓疱型痤疮的经典方剂。从颠倒散治疗痤疮的中医理论基础、临床应用基础、化学成分分析和作用机制角度进行整理,阐述了颠倒散治疗痤疮的药效物质基础。从质量传递和成分可溯性、成分特有性、成分与有效性关联、复方配伍环境及成分可测性角度预测了颠倒散治疗痤疮的质量标志物(Q-marker),结果提示大黄酸、大黄素、芦荟大黄素、单质硫可作为颠倒散治疗痤疮的Q-marker。本研究为深入探究经典方剂颠倒散治疗痤疮的药效物质基础、质量把控和作用机制等研究提供参考。
中文关键词:颠倒散  痤疮  药效物质基础  作用机制  质量标志物
 
Pharmacodynamical Material Basis and Mechanism of Diandao Powder in the Treatment of Acne and Predictive Analysis of Its Q-markers
Abstract:Diandao Powder (DDP), originated from Golden Mirror of the Medical Tradition (Yizong Jinjian) in the Qing Dynasty, is a classic prescription for treating liquor residue, pulmonary wind acne, blackhead acne, seborrheic dermatitis, and popular pustular acne in modern clinical practice. In this study, the pharmacodynamical material basis of DDP in the treatment of acne was described from the perspective of the theoretical basis of traditional Chinese medicine, the basis of clinical application, and its chemical composition. After reviewing the mechanism of DDP, its Q-markers in the treatment of acne were predicted from the perspectives of quality transmission, component traceability, component specificity, association between components and effectiveness, compatibility environment of compound, and component measurability. The results suggested that rhein, emodin, aloe-emodin, and elemental sulfur could be used as Q-markers for DDP in the treatment of acne. This study provided scientific references for further exploring the efficacy basis, quality control, and mechanism of the classic prescription DDP in the treatment of acne.
keywords:Diandao Powder  acne  pharmacodynamical material basis  mechanism  Q-markers
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