| Abstract:Objective: To compare the volatile oil components and pharmacological activities of five kinds of dried roots of Bupleurum (Bupleurum chinense DC., Bupleurum scorzonerifolium Willd., Bupleurum marginatum var. stenophyllum (Wolff) Shan et Y.Li, Bupleurum marginatum Wall. ex DC., Bupleurum smithii Wolff) based on gas chromatography-mass spectrometry (GC-MS) and network pharmacology. Methods: The volatile oil in the roots of five kinds of Radix Bupleuri was extracted by steam distillation. The components in the volatile oil were analyzed by GC-MS. The "component-target" networks were constructed and KEGG enrichment analysis was carried out. Results: A total of 55 volatile oil compounds of Radix Bupleuri were identified. There are some differences in the composition of volatile oils from five kinds of Radix Bupleuri. The results of network pharmacology showed that five kinds of Radix Bupleuri volatile oils had similar targets (NFKB1, PIK3R1, PIK3CD, NOS2, etc.)., such as NFKB1, PIK3R1, PIK3CD, NOS2 et al. And their common core target acts on neuroactive ligand-receptor interaction, neutrophil extracellular trap formation, sphingolipid signaling pathway, small cell lung cancer and et al. Conclusion: The five kinds of volatile oils of Radix Bupleuri have the potential to substitute each other in anti-infection, anti-inflammation, neuroprotection and anti-tumor. |
