含马兜铃酸的中药现状及相关问题思考
投稿时间:2024-06-21  修订日期:2024-07-01   点此下载全文
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作者中文名作者英文名单位中文名单位英文名E-Mail
戴忠* Dai Zhong 中国食品药品检定研究院 北京 National Institutes for Food and Drug Control daizhong@nifdc.org.cn 
刘静△ Liu Jing△ 中国食品药品检定研究院 北京 National Institutes for Food and Drug Control liujing_zsm@126.com 
郭日新 Guo Rixin 中国食品药品检定研究院 北京 National Institutes for Food and Drug Control
肖萌 Xiao Meng 中国食品药品检定研究院 北京 National Institutes for Food and Drug Control
魏锋 Wei Feng 中国食品药品检定研究院 北京 National Institutes for Food and Drug Control weifeng@nifdc.org.cn 
马双成 Ma Shuangcheng 国家药典委员会 北京 /
基金项目:] 2022年度国家药品标准制修订研究课题(2022Z16);药品监管科学全国重点实验室课题(2023SKLDRS0102)
中文摘要:马兜铃酸的安全性问题一直以来引起国际社会的广泛关注,我国是中药资源大国,涉及的马兜铃科马兜铃属和细辛属中药均含有马兜铃酸,这引起了人们对使用含马兜铃酸中药安全性的担忧。科学工作者们做了大量研究工作,从不同角度回答了马兜铃酸的安全风险问题,国家也出台了多项措施控制马兜铃酸的安全风险。本文从化学、毒性、检测等多方面系统综述了含马兜铃酸中药现状并提出了合理化建议,为含马兜铃酸中药的进一步研究和科学监管提供参考。
中文关键词:马兜铃酸  毒性中药  检测  限度
 
Current Situation and Thinking of Aristolochic Acids in Traditional Chinese Medicine
Abstract:The safety of aristolochic acid has been widely concerned by the international community. China is rich in Chinese herbal resources. Aristolochia and asarum herbals contain aristolochia acid, which causes people to worry about the safety of using this kind of Chinese herbals. Scientists have done a lot of research to evaluate the safety risk of aristolochic acid. And the regulatory agency has also taken a number of measures to control the safety risks of aristolochic acid. In this paper, current situation of aristolochic acid-containing Chinese medicine was systematically reviewed from the aspects of chemistry, toxicity, detection and so on. And some reasonable suggestions were put forward to provide reference for further research and scientific supervision of aristolochic acid-containing Chinese medicine.
keywords:aristolochic  acids, toxicity, Traditional  Chinese Medicine, detection, limitation
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