| 基于经典方桔梗汤的桔梗-甘草药对配伍研究 |
| 投稿时间：2020-02-27 点此下载全文
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| 引用本文：汪聪聪,张玉玲,耿文洁,桂双英,彭代银,王举涛.基于经典方桔梗汤的桔梗-甘草药对配伍研究[J].中国现代中药,2021,23(5):826-831 |
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| 摘要点击次数: 348 |
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| 基金项目:安徽省高等学校自然科学研究基金重点项目（KJ2019A0462）；安徽省科技重大专项（18030801128）；安徽中医药大学校级探索性科研项目（2017HXTS31，2017HXTS2）；中药研究与开发安徽省重点实验室开放基金项目（AKLPDC202004） |
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| 中文摘要:目的：基于经典方桔梗汤分析桔梗-甘草药对不同比例配伍后甘草中活性成分甘草苷与甘草酸含量变化研究，阐释中药合理配伍的科学内涵，考察不同产地桔梗药材配伍甘草对复方桔梗汤指标性活性成分含量变化的影响，验证该配伍比例对不同产地桔梗药材的普适性。方法：固定甘草的量，增加桔梗，选定5组桔梗甘草配伍比例（1∶3、1∶2、1∶1、2∶1、3∶1），探讨不同配伍比例对甘草有效成分溶出的影响。按古方水煎法制备单味甘草、不同产地单味桔梗、不同产地桔梗配伍甘草的复方桔梗汤样品，分别采用蒸发光散射检测器（ELSD）、高效液相色谱法（HPLC）测定其中桔梗皂苷D、甘草酸和甘草苷的含量。结果：不同配伍比例桔梗-甘草研究中，桔梗-甘草1∶2配伍时复方中甘草苷和甘草酸含量最高；不同产地桔梗配伍甘草后，桔梗皂苷D、甘草酸和甘草苷的含量均较单味药材中含量有所增加。结论：在固定甘草量条件下，随着桔梗占比增大（1∶3、1∶2），甘草苷与甘草酸含量有所增加，但随着桔梗占比继续增大，甘草苷与甘草酸含量不再增加，甚至出现减少情况；桔梗与甘草配伍后有效成分含量的变化说明了两者配伍具有科学性与合理性。 |
| 中文关键词:桔梗汤 药对 配伍比例 产地 含量测定 |
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| Study on Herbal Drug Pair of Platycodonis Radix and Glycyrrhizae Radix et Rhizoma in Classical Prescription Jiegeng Tang |
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| Abstract:Objective：Based on the classical prescription Jiegeng Tang，the content changes of the active ingredients liquiritin and glycyrrhizic acid in Glycyrrhizae Radix et Rhizoma before and after different compatibility ratio of Platycodonis Radix and Glycyrrhizae Radix et Rhizoma were analyzed to explain the scientific connotation of reasonable compatibility of traditional Chinese medicine，and investigate the changes of the content of the active index components of Jiegeng Tang by the compatibility of Glycyrrhizae Radix et Rhizoma with Platycodonis Radix in different origins for verification of the compatibility ratio. Methods：With fixed Glycyrrhizae Radix et Rhizoma dosage，through increase of the dosage of Platycodonis Radix with 5 groups of compatibility ratio （1∶3，1∶2，1∶1，2∶1，3∶1），the dissolution of effective components of Glycyrrhizae Radix et Rhizoma with different compatibility ratio influences was explored. The compound Jiegeng Tang samples of single Glycyrrhizae Radix et Rhizoma，single Platycodonis Radix of different origins，and PR of different origins with Glycyrrhizae Radix et Rhizoma were prepared according to the ancient decoction method，and the contents of platycodin D，glycyrrhizic acid，and liquiritin were determined by ELSD and HPLC respectively. Results：In the study of Platycodonis Radix with different compatibility ratio，the Platycodonis Radix：Glycyrrhizae Radix et Rhizoma （1∶2） showed the best results. Platycodonis Radix combined with Glycyrrhizae Radix et Rhizoma of different origins，the content of platycodin D，glycyrrhizic acid and liquiritin showed all higher values than those in single herbs. Conclusion：With a fixed amount of Glycyrrhizae Radix et Rhizoma，the content of liquiritin and glycyrrhizic acid increased as the proportion of Platycodonis Radix increased （1∶3，1∶2），but with the proportion of Platycodonis Radix contiuing increasing，the content of glycyrrhizic acid no longer increased，or even decreased；the changes in the content of active ingredients after the compatibility of Platycodonis Radix and Glycyrrhizae Radix et Rhizoma shows that the compatibility of the two is scientific and reasonable. |
| keywords:Jiegeng Tang a pair of herbal drugs compatibility proportion origins determination |
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